FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981036391> ?p ?o ?g. }

• W1981036391 abstract "Summary Human T‐lymphotropic virus 1 (HTLV‐1) can cause HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP). The objective of this study was to gain insight into the pathogenesis of HAM/TSP by focusing on the CD8 + T‐cell response. Twenty‐three HTLV‐1‐seronegative controls (SC), 29 asymptomatic HTLV‐1 carriers (AC) and 48 patients with HAM/TSP were enrolled in the study. We evaluated the production of interferon‐γ (IFN‐γ) in peripheral blood mononuclear cells stimulated with Tax overlapping peptides, the expression of genes related to the CD8 + cytotoxic T‐cell response, the frequency of CD4 + Foxp3 + cells and of dendritic cells, and the HTLV‐1 provirus load (PVL). The frequency of cells producing IFN‐γ in response to Tax 161–233, but not to Tax 11–19, discriminated patients with HAM/TSP from AC. The increased pro‐inflammatory response observed in patients with HAM/TSP was shared by AC with a high PVL, who also exhibited lower levels of granzyme H mRNA in unstimulated CD8 + T cells than AC with a low PVL. Patients with HAM/TSP showed higher frequencies of CD4 + Foxp3 + cells and lower frequencies of plasmacytoid dendritic cells (pDC) than AC. Our findings are consistent with a model in which HTLV‐1, along with the host genetic background, drives quantitative and qualitative changes in pDC and CD4 + Foxp3 + cells that lead to a predominance of inflammatory responses over lytic responses in the CD8 + T‐cell response of individuals predisposed to develop HAM/TSP." @default.
• W1981036391 created "2016-06-24" @default.
• W1981036391 creator A5027205280 @default.
• W1981036391 creator A5032244298 @default.
• W1981036391 creator A5035298233 @default.
• W1981036391 creator A5040716549 @default.
• W1981036391 creator A5058285355 @default.
• W1981036391 creator A5063361589 @default.
• W1981036391 creator A5064443855 @default.
• W1981036391 creator A5065441719 @default.
• W1981036391 date "2009-08-04" @default.
• W1981036391 modified "2023-10-16" @default.
• W1981036391 title "IFN-γ production in response to Tax 161-233, and frequency of CD4⁺ Foxp3⁺and Lin⁻ HLA-DR^high CD123⁺cells, discriminate HAM/TSP patients from asymptomatic HTLV-1-carriers in a Peruvian population" @default.
• W1981036391 cites W1481479299 @default.
• W1981036391 cites W1494072722 @default.
• W1981036391 cites W1536745120 @default.
• W1981036391 cites W1577577364 @default.
• W1981036391 cites W1880674038 @default.
• W1981036391 cites W1964804566 @default.
• W1981036391 cites W1976997925 @default.
• W1981036391 cites W1977581620 @default.
• W1981036391 cites W1981906666 @default.
• W1981036391 cites W1986288288 @default.
• W1981036391 cites W2003276121 @default.
• W1981036391 cites W2011173604 @default.
• W1981036391 cites W2019046407 @default.
• W1981036391 cites W2019987233 @default.
• W1981036391 cites W2021057394 @default.
• W1981036391 cites W2060437233 @default.
• W1981036391 cites W2060456611 @default.
• W1981036391 cites W2062989840 @default.
• W1981036391 cites W2065581745 @default.
• W1981036391 cites W2084714153 @default.
• W1981036391 cites W2087169490 @default.
• W1981036391 cites W2088143274 @default.
• W1981036391 cites W2088357375 @default.
• W1981036391 cites W2091813499 @default.
• W1981036391 cites W2110834729 @default.
• W1981036391 cites W2122782505 @default.
• W1981036391 cites W2123483730 @default.
• W1981036391 cites W2126838772 @default.
• W1981036391 cites W2127432084 @default.
• W1981036391 cites W2131578560 @default.
• W1981036391 cites W2132133285 @default.
• W1981036391 cites W2144063967 @default.
• W1981036391 cites W2145273296 @default.
• W1981036391 cites W2157155233 @default.
• W1981036391 cites W2157527261 @default.
• W1981036391 cites W2158178382 @default.
• W1981036391 cites W2165109848 @default.
• W1981036391 cites W2167533463 @default.
• W1981036391 cites W2170691975 @default.
• W1981036391 doi "https://doi.org/10.1111/j.1365-2567.2009.03082.x" @default.
• W1981036391 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2753904" @default.
• W1981036391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19740339" @default.
• W1981036391 hasPublicationYear "2009" @default.
• W1981036391 type Work @default.
• W1981036391 sameAs 1981036391 @default.
• W1981036391 citedByCount "31" @default.
• W1981036391 countsByYear W19810363912012 @default.
• W1981036391 countsByYear W19810363912013 @default.
• W1981036391 countsByYear W19810363912014 @default.
• W1981036391 countsByYear W19810363912015 @default.
• W1981036391 countsByYear W19810363912016 @default.
• W1981036391 countsByYear W19810363912017 @default.
• W1981036391 countsByYear W19810363912018 @default.
• W1981036391 countsByYear W19810363912019 @default.
• W1981036391 countsByYear W19810363912020 @default.
• W1981036391 countsByYear W19810363912021 @default.
• W1981036391 countsByYear W19810363912023 @default.
• W1981036391 crossrefType "journal-article" @default.
• W1981036391 hasAuthorship W1981036391A5027205280 @default.
• W1981036391 hasAuthorship W1981036391A5032244298 @default.
• W1981036391 hasAuthorship W1981036391A5035298233 @default.
• W1981036391 hasAuthorship W1981036391A5040716549 @default.
• W1981036391 hasAuthorship W1981036391A5058285355 @default.
• W1981036391 hasAuthorship W1981036391A5063361589 @default.
• W1981036391 hasAuthorship W1981036391A5064443855 @default.
• W1981036391 hasAuthorship W1981036391A5065441719 @default.
• W1981036391 hasBestOaLocation W19810363912 @default.
• W1981036391 hasConcept C137061746 @default.
• W1981036391 hasConcept C153911025 @default.
• W1981036391 hasConcept C154317977 @default.
• W1981036391 hasConcept C159047783 @default.
• W1981036391 hasConcept C167672396 @default.
• W1981036391 hasConcept C169760540 @default.
• W1981036391 hasConcept C185592680 @default.
• W1981036391 hasConcept C202751555 @default.
• W1981036391 hasConcept C203014093 @default.
• W1981036391 hasConcept C2522874641 @default.
• W1981036391 hasConcept C2776090121 @default.
• W1981036391 hasConcept C2776238826 @default.
• W1981036391 hasConcept C2776392238 @default.
• W1981036391 hasConcept C2776913467 @default.
• W1981036391 hasConcept C2777604421 @default.
• W1981036391 hasConcept C2779727006 @default.
• W1981036391 hasConcept C2780775167 @default.
• W1981036391 hasConcept C55493867 @default.
• W1981036391 hasConcept C86803240 @default.
• W1981036391 hasConcept C8891405 @default.

• next