Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981036736> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1981036736 endingPage "341" @default.
- W1981036736 startingPage "331" @default.
- W1981036736 abstract "DNA from untreated L-cells had a weight average molecular weight (Mw) of 5.7 ± 0.58·108 daltons as measured by sedimentation in an alkaline sucrose gradient. This value was reduced by one half after the cells were treated for 1 h with 8 μg/ml of N-methyl-N-nitrosourea (MNUA), 34 μg/ml of methyl methanesulfonate (MMS) or 0.16 μg/ml of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). That dose of MNUA produced 52 methylations per 5.7·108 daltons DNA. 20% of these were not purine derivatives and were assumed to contain some phosphotriesters. That dose of MMS (above) produced 290 methylations per 5.7·108 daltons DNA and about 14% of these were not purine derivatives. The rates of loss of methylated purines from DNA were 2.3% per hour for 7-methylguanine (7-MeG), 7.4% per hour for 3-methyladenine (3-MeA) and no detectable loss of O6-methylguanine (O6-MeG) over a 12 h period. Since phosphotriesters are alkali-labile the single-strand breaks probably arose from this structure and did not form within the cell. This conclusion is supported by the following considerations. MNUA was more effective than MMS at reducing the molecular weight of DNA, as measured in alkaline medium. The greater SN1 character of MNUA would cause a greater formation of phosphotriesters than would MMS." @default.
- W1981036736 created "2016-06-24" @default.
- W1981036736 creator A5029165404 @default.
- W1981036736 creator A5069339348 @default.
- W1981036736 date "1973-09-01" @default.
- W1981036736 modified "2023-10-16" @default.
- W1981036736 title "The nature of single-strand breaks in DNA following treatment of L-cells with methylating agents" @default.
- W1981036736 cites W117870350 @default.
- W1981036736 cites W1516026837 @default.
- W1981036736 cites W1609549973 @default.
- W1981036736 cites W1920518078 @default.
- W1981036736 cites W1964834371 @default.
- W1981036736 cites W1972936814 @default.
- W1981036736 cites W1973914008 @default.
- W1981036736 cites W1982908731 @default.
- W1981036736 cites W1989737739 @default.
- W1981036736 cites W1990290264 @default.
- W1981036736 cites W1990493392 @default.
- W1981036736 cites W1993405323 @default.
- W1981036736 cites W2026670518 @default.
- W1981036736 cites W2034740026 @default.
- W1981036736 cites W2038887477 @default.
- W1981036736 cites W2058271345 @default.
- W1981036736 cites W2067158954 @default.
- W1981036736 cites W2070680969 @default.
- W1981036736 cites W2073681954 @default.
- W1981036736 cites W2079667271 @default.
- W1981036736 cites W2101766645 @default.
- W1981036736 cites W2155121310 @default.
- W1981036736 cites W2217356684 @default.
- W1981036736 doi "https://doi.org/10.1016/0027-5107(73)90234-0" @default.
- W1981036736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4356894" @default.
- W1981036736 hasPublicationYear "1973" @default.
- W1981036736 type Work @default.
- W1981036736 sameAs 1981036736 @default.
- W1981036736 citedByCount "64" @default.
- W1981036736 crossrefType "journal-article" @default.
- W1981036736 hasAuthorship W1981036736A5029165404 @default.
- W1981036736 hasAuthorship W1981036736A5069339348 @default.
- W1981036736 hasConcept C143425029 @default.
- W1981036736 hasConcept C153911025 @default.
- W1981036736 hasConcept C169586020 @default.
- W1981036736 hasConcept C181199279 @default.
- W1981036736 hasConcept C185592680 @default.
- W1981036736 hasConcept C2776476023 @default.
- W1981036736 hasConcept C2776694085 @default.
- W1981036736 hasConcept C2776900477 @default.
- W1981036736 hasConcept C2776946711 @default.
- W1981036736 hasConcept C3017648133 @default.
- W1981036736 hasConcept C54355233 @default.
- W1981036736 hasConcept C552990157 @default.
- W1981036736 hasConcept C55493867 @default.
- W1981036736 hasConcept C71240020 @default.
- W1981036736 hasConcept C86803240 @default.
- W1981036736 hasConceptScore W1981036736C143425029 @default.
- W1981036736 hasConceptScore W1981036736C153911025 @default.
- W1981036736 hasConceptScore W1981036736C169586020 @default.
- W1981036736 hasConceptScore W1981036736C181199279 @default.
- W1981036736 hasConceptScore W1981036736C185592680 @default.
- W1981036736 hasConceptScore W1981036736C2776476023 @default.
- W1981036736 hasConceptScore W1981036736C2776694085 @default.
- W1981036736 hasConceptScore W1981036736C2776900477 @default.
- W1981036736 hasConceptScore W1981036736C2776946711 @default.
- W1981036736 hasConceptScore W1981036736C3017648133 @default.
- W1981036736 hasConceptScore W1981036736C54355233 @default.
- W1981036736 hasConceptScore W1981036736C552990157 @default.
- W1981036736 hasConceptScore W1981036736C55493867 @default.
- W1981036736 hasConceptScore W1981036736C71240020 @default.
- W1981036736 hasConceptScore W1981036736C86803240 @default.
- W1981036736 hasIssue "3" @default.
- W1981036736 hasLocation W19810367361 @default.
- W1981036736 hasLocation W19810367362 @default.
- W1981036736 hasOpenAccess W1981036736 @default.
- W1981036736 hasPrimaryLocation W19810367361 @default.
- W1981036736 hasRelatedWork W1596145695 @default.
- W1981036736 hasRelatedWork W1600008047 @default.
- W1981036736 hasRelatedWork W1972022817 @default.
- W1981036736 hasRelatedWork W2021358753 @default.
- W1981036736 hasRelatedWork W2035104364 @default.
- W1981036736 hasRelatedWork W2046925551 @default.
- W1981036736 hasRelatedWork W2413319058 @default.
- W1981036736 hasRelatedWork W2952850305 @default.
- W1981036736 hasRelatedWork W4254211522 @default.
- W1981036736 hasRelatedWork W1555636732 @default.
- W1981036736 hasVolume "19" @default.
- W1981036736 isParatext "false" @default.
- W1981036736 isRetracted "false" @default.
- W1981036736 magId "1981036736" @default.
- W1981036736 workType "article" @default.