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- W1981075243 abstract "We recently described a new method for the cotside measurement of CBF in sick newborn infants using NIRS (Lancet 1988;ii:770). The method is based on the Fick principle and uses small changes of inspired oxygen concentration to cause changes in cerebral oxyhaemoglobin concentration (DHbO2). DHbO2 behaves as an intravascular tracer which can be observed using NIRS. Measurements made on the adult forearm by this method and be venous occlusion plethysmography showed good correspondence (n=14, y=0.91x+0.16, r=0.94, p<0.001). (J. Physiol., in press.) A computerised Monte Carlo simulation of the method predicts an intra-subject coefficient of variation (cv) of 16%. We have estimated cv from repeated measurements (4-10, median 7) in 8 sick but stable infants (gestation 26-29 weeks; age 1-12 days). Mean CBF ranged from 8 to 20 ml/100 g.min (median 17.5). The intrasubject cv ranged from 8% to 27%, mean 18%. NIRS thus allows repeated, non-invasive measurements of CBF at the cotside with acceptable precision. It has the potential to be a practical clinical and research method. Supported by the MRC, Wellcome Trust and Hamamatsu Photonics KK." @default.
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- W1981075243 date "1989-11-01" @default.
- W1981075243 modified "2023-09-27" @default.
- W1981075243 title "PRECISION OF CEREBRAL BLOOD FLOW (CBF) MEASUREMENT BY NEAR INFRARED SPECTROSCOPY (NIRS)" @default.
- W1981075243 doi "https://doi.org/10.1203/00006450-198911000-00127" @default.
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