Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981076294> ?p ?o ?g. }
- W1981076294 endingPage "35" @default.
- W1981076294 startingPage "28" @default.
- W1981076294 abstract "Hepcidin, a 25 amino-acid liver hormone, has recently emerged as the key regulator of iron homeostasis. Proteomic studies in limited number of subjects have shown that biological fluids can also contain truncated isoforms, whose role remains to be elucidated. We report, for the first time, data about serum levels of the hepcidin-20 isoform (hep-20) in a general population, taking advantage of the Val Borbera (VB) study where hepcidin-25 (hep-25) was measured by SELDI-TOF-MS. Detectable amount of hep-20 were found in sera from 854 out of 1577 subjects (54.2%), and its levels were about 14% of hep-25 levels. A small fraction of subjects (n=30, 1.9%) had detectable hep-20 but undetectable hep-25. In multivariate regression models, significant predictors of hep-20 were hep-25 and age in males, and hep-25, age, serum ferritin and body mass index in females. Of note, the hep-25:hep-20 ratio was not constant in the VB population, but increased progressively with increasing ferritin levels. This is not consistent with the simplistic view of hep-20 as a mere catabolic byproduct of hep-25. Although a possible active regulation of hep-20 production needs further confirmation, our results may also have implications for immunoassays for serum hepcidin based on antibodies lacking specificity for hep-25. This article is part of a Special Issue entitled: Integrated omics." @default.
- W1981076294 created "2016-06-24" @default.
- W1981076294 creator A5002874332 @default.
- W1981076294 creator A5003819997 @default.
- W1981076294 creator A5021394215 @default.
- W1981076294 creator A5023996952 @default.
- W1981076294 creator A5038797557 @default.
- W1981076294 creator A5041306142 @default.
- W1981076294 creator A5048435323 @default.
- W1981076294 creator A5051991055 @default.
- W1981076294 creator A5057071664 @default.
- W1981076294 creator A5064212109 @default.
- W1981076294 creator A5068109489 @default.
- W1981076294 creator A5081960790 @default.
- W1981076294 creator A5085049981 @default.
- W1981076294 date "2012-12-01" @default.
- W1981076294 modified "2023-10-05" @default.
- W1981076294 title "Serum levels of the hepcidin-20 isoform in a large general population: The Val Borbera study" @default.
- W1981076294 cites W1938840097 @default.
- W1981076294 cites W1966383205 @default.
- W1981076294 cites W1979733076 @default.
- W1981076294 cites W1980042430 @default.
- W1981076294 cites W1990812408 @default.
- W1981076294 cites W2004451551 @default.
- W1981076294 cites W2023704452 @default.
- W1981076294 cites W2025063713 @default.
- W1981076294 cites W2027624389 @default.
- W1981076294 cites W2033301706 @default.
- W1981076294 cites W2034082710 @default.
- W1981076294 cites W2037708841 @default.
- W1981076294 cites W2054421541 @default.
- W1981076294 cites W2057198053 @default.
- W1981076294 cites W2062594867 @default.
- W1981076294 cites W2073419951 @default.
- W1981076294 cites W2080424930 @default.
- W1981076294 cites W2081098766 @default.
- W1981076294 cites W2107704801 @default.
- W1981076294 cites W2109945939 @default.
- W1981076294 cites W2113040826 @default.
- W1981076294 cites W2116765339 @default.
- W1981076294 cites W2121300659 @default.
- W1981076294 cites W2130613991 @default.
- W1981076294 cites W2132136681 @default.
- W1981076294 cites W2144753011 @default.
- W1981076294 cites W2155679596 @default.
- W1981076294 doi "https://doi.org/10.1016/j.jprot.2012.08.006" @default.
- W1981076294 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3509339" @default.
- W1981076294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22951294" @default.
- W1981076294 hasPublicationYear "2012" @default.
- W1981076294 type Work @default.
- W1981076294 sameAs 1981076294 @default.
- W1981076294 citedByCount "29" @default.
- W1981076294 countsByYear W19810762942012 @default.
- W1981076294 countsByYear W19810762942013 @default.
- W1981076294 countsByYear W19810762942014 @default.
- W1981076294 countsByYear W19810762942015 @default.
- W1981076294 countsByYear W19810762942016 @default.
- W1981076294 countsByYear W19810762942017 @default.
- W1981076294 countsByYear W19810762942018 @default.
- W1981076294 countsByYear W19810762942019 @default.
- W1981076294 countsByYear W19810762942022 @default.
- W1981076294 countsByYear W19810762942023 @default.
- W1981076294 crossrefType "journal-article" @default.
- W1981076294 hasAuthorship W1981076294A5002874332 @default.
- W1981076294 hasAuthorship W1981076294A5003819997 @default.
- W1981076294 hasAuthorship W1981076294A5021394215 @default.
- W1981076294 hasAuthorship W1981076294A5023996952 @default.
- W1981076294 hasAuthorship W1981076294A5038797557 @default.
- W1981076294 hasAuthorship W1981076294A5041306142 @default.
- W1981076294 hasAuthorship W1981076294A5048435323 @default.
- W1981076294 hasAuthorship W1981076294A5051991055 @default.
- W1981076294 hasAuthorship W1981076294A5057071664 @default.
- W1981076294 hasAuthorship W1981076294A5064212109 @default.
- W1981076294 hasAuthorship W1981076294A5068109489 @default.
- W1981076294 hasAuthorship W1981076294A5081960790 @default.
- W1981076294 hasAuthorship W1981076294A5085049981 @default.
- W1981076294 hasBestOaLocation W19810762941 @default.
- W1981076294 hasConcept C104317684 @default.
- W1981076294 hasConcept C126322002 @default.
- W1981076294 hasConcept C134018914 @default.
- W1981076294 hasConcept C185592680 @default.
- W1981076294 hasConcept C203014093 @default.
- W1981076294 hasConcept C2776768029 @default.
- W1981076294 hasConcept C2778248108 @default.
- W1981076294 hasConcept C2778319317 @default.
- W1981076294 hasConcept C2908647359 @default.
- W1981076294 hasConcept C53345823 @default.
- W1981076294 hasConcept C55493867 @default.
- W1981076294 hasConcept C62231903 @default.
- W1981076294 hasConcept C63645605 @default.
- W1981076294 hasConcept C71315377 @default.
- W1981076294 hasConcept C71924100 @default.
- W1981076294 hasConcept C86803240 @default.
- W1981076294 hasConcept C96942376 @default.
- W1981076294 hasConcept C99454951 @default.
- W1981076294 hasConceptScore W1981076294C104317684 @default.
- W1981076294 hasConceptScore W1981076294C126322002 @default.
- W1981076294 hasConceptScore W1981076294C134018914 @default.