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• W1981100994 abstract "Lee, Y.-H., Channon, J. Y., Matsuura, T., Schwartzman, J. D., Shin, D.-W., and Kasper, L. H. 1999. Functional and quantitative analysis of splenic T cell immune responses following oralToxoplasma gondiiinfection in mice.Experimental Parasitology91,212–221. Immunity toToxoplasma gondiiis mediated primarily by the host T cell response. Although there is considerable information regarding host immunity following intraperitoneal infection with tachyzoites, little information is available regarding naturally acquired infection following peroral infection with bradyzoites. In this study, a sequential quantitative analysis of the cell-mediated immune response was performed at the single cell level. To assess the kinetics of this response and parasitic loads, inbred mice were orally infected with the 76K strain bradyzoites ofT. gondii.Within 24 h of infection, follicular hyperplasia followed by infiltration with histiocytes, macrophages, and apoptotic bodies was observed in the spleens of infected mice.T. gondiiwere detected from day 1, and counts increased gradually during the experimental period. Splenocyte DNA synthesis to antigen and mitogen was severely suppressed at days 7 and 10. The percentages of NK1.1+or δγ T cells were increased from day 1, whereas CD4+and CD8α+T cells were signficantly increased after day 7 postinfection. CD25 expression and intracellular IFN-γ production increased in NK1.1+cells on day 1 and by all other T cell subsets after day 4. Intracellular IL-4 did not increase until day 7, and IL-10 production was increased in all T cell subsets after day 4. Together, these findings indicate that oral infection withT. gondiistimulates a strong cellular immune response that appears to polarize toward an early Th1 response. However, within 7 days, a strong immune Th2 regulatory response as well as high parasitic loads can be observed, with a reduction in lymphoproliferation to mitogen stimulation, increased production of IL-4 and IL-10, and evidence of T cell apoptosis in the splenic immune compartment." @default.
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• W1981100994 date "1999-03-01" @default.
• W1981100994 modified "2023-09-30" @default.
• W1981100994 title "Functional and Quantitative Analysis of Splenic T Cell Immune Responses Following OralToxoplasma gondiiInfection in Mice" @default.
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• W1981100994 doi "https://doi.org/10.1006/expr.1998.4359" @default.
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