Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981103324> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1981103324 abstract "In previous studies, long term treatment with ethanol has been shown to enhance brain 5-hydroxytryptamine 5-(HT) metabolism by increasing the activity of the regulatory enzyme tryptophan hydroxylase and or availability of circulating tryptophan secondarily to an inhibition of hepatic tryptophan pyrrolase. In the present study ethanol treatment given for two weeks decreased hepatic apo-tryptophan pyrrolase but not total tryptophan pyrrolase activity in rats. Tryptophan levels in plasma and brain did not increase significantly. But there was a marked increase of 5-HT but not 5-hydroxyindoleacetic acid (5-HIAA) concentration in brain, suggesting a possible increase in the activity of tryptophan hydroxylase. The effect of a tryptophan load on brain 5-HT metabolism was therefore compared in controls and ethanol treated rats. One hour after tryptophan injection (50 mg/kg i.p.) plasma concentrations of total and free tryptophan were identical in controls and ethanol treated rats, but the increases of brain tryptophan 5-HT and 5-HIAA were considerably greater in the latter group. The results are consistent with long term ethanol treatment enhancing brain serotonin metabolism and show that brain uptake/utilization of exogenous tryptophan is increased in ethanol treated rats and may be useful to understand the role and possible mechanism of tryptophan/serotonin involvement in mood regulation." @default.
- W1981103324 created "2016-06-24" @default.
- W1981103324 creator A5019048394 @default.
- W1981103324 date "1990-01-01" @default.
- W1981103324 modified "2023-10-18" @default.
- W1981103324 title "Injected tryptophan increases brain but not plasma tryptophan levels more in ethanol treated rats" @default.
- W1981103324 cites W110237296 @default.
- W1981103324 cites W146927540 @default.
- W1981103324 cites W1798211609 @default.
- W1981103324 cites W1944697741 @default.
- W1981103324 cites W1965110379 @default.
- W1981103324 cites W1973533531 @default.
- W1981103324 cites W1975127652 @default.
- W1981103324 cites W1982839956 @default.
- W1981103324 cites W1985676682 @default.
- W1981103324 cites W1996970876 @default.
- W1981103324 cites W2000403320 @default.
- W1981103324 cites W2002660252 @default.
- W1981103324 cites W2022030870 @default.
- W1981103324 cites W2037511056 @default.
- W1981103324 cites W2038911270 @default.
- W1981103324 cites W2040981420 @default.
- W1981103324 cites W2059940792 @default.
- W1981103324 cites W2061099844 @default.
- W1981103324 cites W2068535052 @default.
- W1981103324 cites W2069782299 @default.
- W1981103324 cites W2079814518 @default.
- W1981103324 cites W2082138874 @default.
- W1981103324 cites W2082325583 @default.
- W1981103324 cites W2084339590 @default.
- W1981103324 cites W2092299253 @default.
- W1981103324 cites W2156536381 @default.
- W1981103324 cites W2313154790 @default.
- W1981103324 cites W231937379 @default.
- W1981103324 cites W2339014335 @default.
- W1981103324 cites W2408892449 @default.
- W1981103324 cites W2415177606 @default.
- W1981103324 cites W2422941767 @default.
- W1981103324 cites W4243238965 @default.
- W1981103324 cites W69812067 @default.
- W1981103324 cites W845493968 @default.
- W1981103324 doi "https://doi.org/10.1016/0024-3205(90)90544-2" @default.
- W1981103324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2215078" @default.
- W1981103324 hasPublicationYear "1990" @default.
- W1981103324 type Work @default.
- W1981103324 sameAs 1981103324 @default.
- W1981103324 citedByCount "14" @default.
- W1981103324 countsByYear W19811033242020 @default.
- W1981103324 crossrefType "journal-article" @default.
- W1981103324 hasAuthorship W1981103324A5019048394 @default.
- W1981103324 hasConcept C126322002 @default.
- W1981103324 hasConcept C134018914 @default.
- W1981103324 hasConcept C170493617 @default.
- W1981103324 hasConcept C185592680 @default.
- W1981103324 hasConcept C2775864247 @default.
- W1981103324 hasConcept C2775951788 @default.
- W1981103324 hasConcept C2776706248 @default.
- W1981103324 hasConcept C2780161600 @default.
- W1981103324 hasConcept C37000724 @default.
- W1981103324 hasConcept C515207424 @default.
- W1981103324 hasConcept C55493867 @default.
- W1981103324 hasConcept C62231903 @default.
- W1981103324 hasConcept C71924100 @default.
- W1981103324 hasConcept C86803240 @default.
- W1981103324 hasConceptScore W1981103324C126322002 @default.
- W1981103324 hasConceptScore W1981103324C134018914 @default.
- W1981103324 hasConceptScore W1981103324C170493617 @default.
- W1981103324 hasConceptScore W1981103324C185592680 @default.
- W1981103324 hasConceptScore W1981103324C2775864247 @default.
- W1981103324 hasConceptScore W1981103324C2775951788 @default.
- W1981103324 hasConceptScore W1981103324C2776706248 @default.
- W1981103324 hasConceptScore W1981103324C2780161600 @default.
- W1981103324 hasConceptScore W1981103324C37000724 @default.
- W1981103324 hasConceptScore W1981103324C515207424 @default.
- W1981103324 hasConceptScore W1981103324C55493867 @default.
- W1981103324 hasConceptScore W1981103324C62231903 @default.
- W1981103324 hasConceptScore W1981103324C71924100 @default.
- W1981103324 hasConceptScore W1981103324C86803240 @default.
- W1981103324 hasLocation W19811033241 @default.
- W1981103324 hasLocation W19811033242 @default.
- W1981103324 hasOpenAccess W1981103324 @default.
- W1981103324 hasPrimaryLocation W19811033241 @default.
- W1981103324 hasRelatedWork W1978610227 @default.
- W1981103324 hasRelatedWork W1979349505 @default.
- W1981103324 hasRelatedWork W1981103324 @default.
- W1981103324 hasRelatedWork W1993278041 @default.
- W1981103324 hasRelatedWork W2002361387 @default.
- W1981103324 hasRelatedWork W2081410104 @default.
- W1981103324 hasRelatedWork W2086379671 @default.
- W1981103324 hasRelatedWork W2106346597 @default.
- W1981103324 hasRelatedWork W2128286595 @default.
- W1981103324 hasRelatedWork W3176784572 @default.
- W1981103324 isParatext "false" @default.
- W1981103324 isRetracted "false" @default.
- W1981103324 magId "1981103324" @default.
- W1981103324 workType "article" @default.