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- W1981112078 abstract "The aim of this study was to characterize the receptor(s) for bombesin (BN) and its homologues (gastrin releasing peptide, GRP; neuromedin B, NMB; neuromedin C, NMC) in guinea pig gallbladder muscle strips. Dose-dependent contractions were induced by all peptides tested (potency: BN = GRP > NMC > NMB, but with similar efficacy: BN = GRP = NMC = NMB). The contractions were resistant to tetrodotoxin, atropine, phentolamine, and propranolol. BN tachyphylaxis (1 μM) abolished subsequent contractile responses to BN, GRP and NMC; and partially antagonized the response to NMB (66 ± 7% inhibition). NMB tachyphylaxis (10 μM) markedly inhibited subsequent contractile responses to NMB (78 ± 5%); and partially antagonized the contractile response to BN (36 ± 4%), GRP (31 ± 12%) and NMC (22 ± 2%). At 1 μM, both [d-Phe6, Des-Met14]-BN(6–14) ethylamide and ICI 216,140, two BN receptor antagonists, reduced the contractile actions of BN (82 ± 4% and 59 ± 8% inhibition, respectively), GRP (75 ± 11% and 45 ± 5%), and NMC (73 ± 9% and 51 ± 6%) while having no marked effect on NMB contractions. Our pharmacological approaches (receptor tachyphylaxis and differential antagonism) provide support for two types of receptors for BN-like peptides on guinea pig gallbladder smooth muscle: a GRP-preferring receptor and a NMB-preferring receptor." @default.
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- W1981112078 title "Pharmacological analysis of receptors for bombesin-related peptides on guinea pig gallbladder smooth muscle" @default.
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- W1981112078 doi "https://doi.org/10.1016/0167-0115(94)90051-5" @default.
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