FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981120411> ?p ?o ?g. }

• W1981120411 endingPage "1022" @default.
• W1981120411 startingPage "995" @default.
• W1981120411 abstract "Chemical probes for free radicals in biology are important tools; fluorescence and chemiluminescence offer high detection sensitivity. This article reviews progress in the development of probes for reactive oxygen and nitrogen species, emphasizing the caution needed in their use. Reactive species include hydrogen peroxide; hydroxyl, superoxide, and thiyl radicals; carbonate radical-anion; and nitric oxide, nitrogen dioxide, and peroxynitrite. Probes based on reduced dyes lack selectivity and may require a catalyst for reaction: despite these drawbacks, dichlorodihydrofluorescein and dihydrorhodamine have been used in well over 2,000 studies. Use in cellular systems requires loading into cells, and minimizing leakage. Reactive species can compete with intracellular antioxidants, changes in fluorescence or luminescence possibly reflecting changes in competing antioxidants rather than free radical generation rate. Products being measured can react further with radicals, and intermediate probe radicals are often reactive toward antioxidants and especially oxygen, to generate superoxide. Common probes for superoxide and nitric oxide require activation to a reactive intermediate; activation is not achieved by the radical of interest and the response is thus additionally sensitive to this first step. Rational use of probes requires understanding and quantitation of the mechanistic pathways involved, and of environmental factors such as oxygen and pH. We can build on this framework of knowledge in evaluating new probes." @default.
• W1981120411 created "2016-06-24" @default.
• W1981120411 creator A5033455586 @default.
• W1981120411 date "2007-10-01" @default.
• W1981120411 modified "2023-10-14" @default.
• W1981120411 title "Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: Progress, pitfalls, and prospects" @default.
• W1981120411 cites W104449421 @default.
• W1981120411 cites W121137283 @default.
• W1981120411 cites W1496204826 @default.
• W1981120411 cites W1498520518 @default.
• W1981120411 cites W1508565500 @default.
• W1981120411 cites W1511153178 @default.
• W1981120411 cites W1511801077 @default.
• W1981120411 cites W1512538844 @default.
• W1981120411 cites W1523213544 @default.
• W1981120411 cites W1532078988 @default.
• W1981120411 cites W1537867938 @default.
• W1981120411 cites W1537962128 @default.
• W1981120411 cites W1549805151 @default.
• W1981120411 cites W1568554038 @default.
• W1981120411 cites W1593050089 @default.
• W1981120411 cites W1598987425 @default.
• W1981120411 cites W1622224404 @default.
• W1981120411 cites W1768117386 @default.
• W1981120411 cites W1775374114 @default.
• W1981120411 cites W1886833444 @default.
• W1981120411 cites W1899685816 @default.
• W1981120411 cites W1964417520 @default.
• W1981120411 cites W1964734062 @default.
• W1981120411 cites W1964736111 @default.
• W1981120411 cites W1965164425 @default.
• W1981120411 cites W1967162316 @default.
• W1981120411 cites W1967729440 @default.
• W1981120411 cites W1967876708 @default.
• W1981120411 cites W1969367445 @default.
• W1981120411 cites W1969564552 @default.
• W1981120411 cites W1969675620 @default.
• W1981120411 cites W1969690844 @default.
• W1981120411 cites W1969806820 @default.
• W1981120411 cites W1970000275 @default.
• W1981120411 cites W1970311180 @default.
• W1981120411 cites W1970607230 @default.
• W1981120411 cites W1972297823 @default.
• W1981120411 cites W1972989329 @default.
• W1981120411 cites W1973294791 @default.
• W1981120411 cites W1973412085 @default.
• W1981120411 cites W1974989148 @default.
• W1981120411 cites W1975091408 @default.
• W1981120411 cites W1975316076 @default.
• W1981120411 cites W1975668301 @default.
• W1981120411 cites W1975717300 @default.
• W1981120411 cites W1975833075 @default.
• W1981120411 cites W1976392585 @default.
• W1981120411 cites W1976417809 @default.
• W1981120411 cites W1977913875 @default.
• W1981120411 cites W1978338738 @default.
• W1981120411 cites W1979424160 @default.
• W1981120411 cites W1980039414 @default.
• W1981120411 cites W1980673780 @default.
• W1981120411 cites W1981891299 @default.
• W1981120411 cites W1982045845 @default.
• W1981120411 cites W1982359906 @default.
• W1981120411 cites W1982370171 @default.
• W1981120411 cites W1983335011 @default.
• W1981120411 cites W1984837568 @default.
• W1981120411 cites W1985091566 @default.
• W1981120411 cites W1985177004 @default.
• W1981120411 cites W198550869 @default.
• W1981120411 cites W1985692248 @default.
• W1981120411 cites W1985724323 @default.
• W1981120411 cites W1986371885 @default.
• W1981120411 cites W1986816129 @default.
• W1981120411 cites W1988054144 @default.
• W1981120411 cites W1988707026 @default.
• W1981120411 cites W1989224728 @default.
• W1981120411 cites W1990465549 @default.
• W1981120411 cites W1990618897 @default.
• W1981120411 cites W1993910598 @default.
• W1981120411 cites W1994259078 @default.
• W1981120411 cites W1995191054 @default.
• W1981120411 cites W1996340661 @default.
• W1981120411 cites W1997050452 @default.
• W1981120411 cites W1998199040 @default.
• W1981120411 cites W1998416542 @default.
• W1981120411 cites W1998485253 @default.
• W1981120411 cites W1999216598 @default.
• W1981120411 cites W1999365716 @default.
• W1981120411 cites W1999445282 @default.
• W1981120411 cites W1999457634 @default.
• W1981120411 cites W1999951567 @default.
• W1981120411 cites W2001251332 @default.
• W1981120411 cites W2001836344 @default.
• W1981120411 cites W2001986762 @default.
• W1981120411 cites W2002891257 @default.
• W1981120411 cites W2003060168 @default.
• W1981120411 cites W2003468545 @default.
• W1981120411 cites W2003754450 @default.
• W1981120411 cites W2003802474 @default.

• next