Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981122694> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1981122694 endingPage "99" @default.
- W1981122694 startingPage "92" @default.
- W1981122694 abstract "We have used immunohistochemical staining to assess the expression of cyclin D1 in formalin-fixed sections of 345 breast carcinomas, dating back 20 years. Clinical follow-up data were available on all patients. Approximately 50% of the tumours showed excessive nuclear staining for cyclin D1 as compared with normal epithelium. Some tumours showed strong cytoplasmic staining in the absence of nuclear staining, and around 25% of the tumours were judged to be negative for nuclear cyclin D1. Contrary to expectations, moderate/strong staining for cyclin D1 was associated with improved relapse-free and overall survival relative to patients whose tumours stained weakly or negatively. Conversely, tumours that were considered negative for cyclin D1 staining had an adverse prognosis, and the poor outcome was further accentuated if the tumours were also oestrogen receptor-negative. A possible explanation for our findings is that tumours in which cyclin D1 levels are abnormally low may have sustained mutations in other genes, such as RBI and that it is this abnormality that has the more significant impact on survival from breast cancer." @default.
- W1981122694 created "2016-06-24" @default.
- W1981122694 creator A5011937902 @default.
- W1981122694 creator A5017165070 @default.
- W1981122694 creator A5019390894 @default.
- W1981122694 creator A5051758709 @default.
- W1981122694 creator A5055450638 @default.
- W1981122694 creator A5060414786 @default.
- W1981122694 creator A5073642929 @default.
- W1981122694 date "1996-04-22" @default.
- W1981122694 modified "2023-10-16" @default.
- W1981122694 title "Cyclin D1 and prognosis in human breast cancer" @default.
- W1981122694 cites W1664492679 @default.
- W1981122694 cites W2009573109 @default.
- W1981122694 cites W2024763413 @default.
- W1981122694 cites W2030537988 @default.
- W1981122694 cites W2032236714 @default.
- W1981122694 cites W2036524303 @default.
- W1981122694 cites W2038252730 @default.
- W1981122694 cites W2039781495 @default.
- W1981122694 cites W2045778975 @default.
- W1981122694 cites W2051618204 @default.
- W1981122694 cites W2119040192 @default.
- W1981122694 cites W31151557 @default.
- W1981122694 doi "https://doi.org/10.1002/(sici)1097-0215(19960422)69:2<92::aid-ijc4>3.0.co;2-q" @default.
- W1981122694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8608989" @default.
- W1981122694 hasPublicationYear "1996" @default.
- W1981122694 type Work @default.
- W1981122694 sameAs 1981122694 @default.
- W1981122694 citedByCount "309" @default.
- W1981122694 countsByYear W19811226942012 @default.
- W1981122694 countsByYear W19811226942013 @default.
- W1981122694 countsByYear W19811226942014 @default.
- W1981122694 countsByYear W19811226942015 @default.
- W1981122694 countsByYear W19811226942016 @default.
- W1981122694 countsByYear W19811226942017 @default.
- W1981122694 countsByYear W19811226942018 @default.
- W1981122694 countsByYear W19811226942019 @default.
- W1981122694 countsByYear W19811226942020 @default.
- W1981122694 countsByYear W19811226942021 @default.
- W1981122694 countsByYear W19811226942022 @default.
- W1981122694 countsByYear W19811226942023 @default.
- W1981122694 crossrefType "journal-article" @default.
- W1981122694 hasAuthorship W1981122694A5011937902 @default.
- W1981122694 hasAuthorship W1981122694A5017165070 @default.
- W1981122694 hasAuthorship W1981122694A5019390894 @default.
- W1981122694 hasAuthorship W1981122694A5051758709 @default.
- W1981122694 hasAuthorship W1981122694A5055450638 @default.
- W1981122694 hasAuthorship W1981122694A5060414786 @default.
- W1981122694 hasAuthorship W1981122694A5073642929 @default.
- W1981122694 hasConcept C120089663 @default.
- W1981122694 hasConcept C121608353 @default.
- W1981122694 hasConcept C126322002 @default.
- W1981122694 hasConcept C142724271 @default.
- W1981122694 hasConcept C199835354 @default.
- W1981122694 hasConcept C204232928 @default.
- W1981122694 hasConcept C2778001805 @default.
- W1981122694 hasConcept C29537977 @default.
- W1981122694 hasConcept C530470458 @default.
- W1981122694 hasConcept C71924100 @default.
- W1981122694 hasConcept C74864618 @default.
- W1981122694 hasConcept C86803240 @default.
- W1981122694 hasConceptScore W1981122694C120089663 @default.
- W1981122694 hasConceptScore W1981122694C121608353 @default.
- W1981122694 hasConceptScore W1981122694C126322002 @default.
- W1981122694 hasConceptScore W1981122694C142724271 @default.
- W1981122694 hasConceptScore W1981122694C199835354 @default.
- W1981122694 hasConceptScore W1981122694C204232928 @default.
- W1981122694 hasConceptScore W1981122694C2778001805 @default.
- W1981122694 hasConceptScore W1981122694C29537977 @default.
- W1981122694 hasConceptScore W1981122694C530470458 @default.
- W1981122694 hasConceptScore W1981122694C71924100 @default.
- W1981122694 hasConceptScore W1981122694C74864618 @default.
- W1981122694 hasConceptScore W1981122694C86803240 @default.
- W1981122694 hasIssue "2" @default.
- W1981122694 hasLocation W19811226941 @default.
- W1981122694 hasLocation W19811226942 @default.
- W1981122694 hasOpenAccess W1981122694 @default.
- W1981122694 hasPrimaryLocation W19811226941 @default.
- W1981122694 hasRelatedWork W1992481203 @default.
- W1981122694 hasRelatedWork W1993946980 @default.
- W1981122694 hasRelatedWork W2013745628 @default.
- W1981122694 hasRelatedWork W2035464821 @default.
- W1981122694 hasRelatedWork W2040976599 @default.
- W1981122694 hasRelatedWork W2351126205 @default.
- W1981122694 hasRelatedWork W2373882175 @default.
- W1981122694 hasRelatedWork W2429210815 @default.
- W1981122694 hasRelatedWork W4284707807 @default.
- W1981122694 hasRelatedWork W50742768 @default.
- W1981122694 hasVolume "69" @default.
- W1981122694 isParatext "false" @default.
- W1981122694 isRetracted "false" @default.
- W1981122694 magId "1981122694" @default.
- W1981122694 workType "article" @default.