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- W1981122935 abstract "T cells play a central role in the cellular part of the immune system and their metabolomic activity is strictly bound to the status of activation. Little is known about the metabolomic resilience of T helper cells in the resting status. Therefore we analyzed the metabolomic profile of non-activated Jurkat T cells under normal and starvation conditions by a two-dimensional GC-MS approach. We detected 52 organic and amino acids in the biological replicates covering the majority of central metabolic pathways. Under starvation conditions 21 analytes representing major metabolic pathways showed a significant down-regulation. For palmitoleic acid a significant up-regulation was detected. The annotation of differentially abundant metabolites to the pathways of TCA-cycle, amino acid metabolism and fatty acid biosynthesis indicating a metabolic switch from glycolytic to lipolytic energy generation upon starvation. Normal 0 21 false false false /* Style Definitions */ table.MsoNormalTable{mso-style-name:Normale Tabelle;mso-tstyle-rowband-size:0;mso-tstyle-colband-size:0;mso-style-noshow:yes;mso-style-parent:;mso-padding-alt:0cm 5.4pt 0cm 5.4pt;mso-para-margin:0cm;mso-para-margin-bottom:.0001pt;mso-pagination:widow-orphan;font-size:10.0pt;font-family:Times New Roman;mso-ansi-language:#0400;mso-fareast-language:#0400;mso-bidi-language:#0400;}" @default.
- W1981122935 created "2016-06-24" @default.
- W1981122935 creator A5013990738 @default.
- W1981122935 date "2013-06-21" @default.
- W1981122935 modified "2023-09-27" @default.
- W1981122935 title "Starvation of Jurkat T cells causes metabolic switch from glycolysis to lipolysis as revealed by comprehensive GC-qMS" @default.
- W1981122935 doi "https://doi.org/10.5584/jiomics.v3i1.129" @default.
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