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• W1981123713 startingPage "2539" @default.
• W1981123713 abstract "The design, synthesis and SAR of sulfonamidopyrrolidinone fXa inhibitors incorporating a new benzamidine isostere, namely aminoisoquinolines, is described. These inhibitors have higher Caco-2 cell permeability than comparable benzamidines and attain higher levels of exposure upon oral dosing. The most potent member 14b (fXa Ki=6 nM) is selective against other serine proteases of interest (>600 fold)." @default.
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• W1981123713 date "1999-09-01" @default.
• W1981123713 modified "2023-10-14" @default.
• W1981123713 title "Aminoisoquinolines: Design and synthesis of an orally active benzamidine isostere for the inhibition of factor XA" @default.
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• W1981123713 doi "https://doi.org/10.1016/s0960-894x(99)00421-7" @default.
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