FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981123857> ?p ?o ?g. }

• W1981123857 abstract "Cardiovascular disease is a major killer worldwide and it is becoming clear the significance of our diet in curbing the disease. Green tea is one of the most widely consumed beverages in the world and has recently attracted significant attention in the scientific community for its health benefits. Its consumption has been associated with lower incidences of coronary artery diseases in the Japanese population. This is mainly attributed to its polyphenolic constituents that include epicatechin, epicatechin gallate, epigallocatechin and epigallocatechin gallate. The aim of this research was to synthesise the four major polyphenols present in green as well as analogues. These compounds would then be tested on H9C2 cardiac myoblast cells and neonatal rat cardiomyocytes in order to further understand the structure-activity relationship as well as potentially improve the cardioprotective function of these polyphenols following oxidative stress and ischaemia/reperfusion injury focusing on the expression of STAT-1 and ERK-1/2 proteins. In H9C2 cardiac myoblast cells following the induction of oxidative stress using H2O2, EGCG, EGC and to a minor extent ECG inhibited STAT-1 activation but not ERK- 1/2 phosphorylation suggesting that although the ERK-1/2 pathway gets activated, its downstream activation of STAT-1 is inhibited by the above polyphenols. EC, on the other hand, inhibited ERK-1/2 activation which in turn cannot activate STAT-1. Quantitative assessment of viable cells showed that pretreatment with EGCG resulted in the lowest amount of non-viable cells reducing cell death by 30%. With neonatal rat cardiomyocytes following ischaemia/reperfusion injury, pretreatment with EGCG reduced the amount of non viable cells by 5% but pretreatment with acetylated EGCG at half the concentration of EGCG reduced non-viable cells by 8%. Structure-activity relationships of the green tea polyphenol analogues identified some key aspects in the structures of the polyphenols important in their cardioprotective function. Results indicated that ABD ring system is required for cardioprotective function but the presence of a third OH group in the ring may not be necessary. Substitution of ring C with benzoic and naphthoic rings improved the potency by more than 13-fold compared to EGCG with EC50 values of 1.60 and 0.77 ?M respectively. Further research into these analogues could realise their potential and contribute to the understanding of the cardioprotective activities of green tea. A review on the previous synthesis approaches, isolation and biosynthesis of the green tea polyphenols is presented in Chapter 1 and also the different signalling pathways of interest in this work. An evaluation of the biological activities of the four major polyphenols is provided in Chapter 3. Experimental procedure and characterisation data are in Chapter 5." @default.
• W1981123857 created "2016-06-24" @default.
• W1981123857 creator A5016261020 @default.
• W1981123857 date "2014-02-28" @default.
• W1981123857 modified "2023-09-24" @default.
• W1981123857 title "Synthesis and cardioprotective activities of greentea polyphenols and their analogues" @default.
• W1981123857 hasPublicationYear "2014" @default.
• W1981123857 type Work @default.
• W1981123857 sameAs 1981123857 @default.
• W1981123857 citedByCount "0" @default.
• W1981123857 crossrefType "dissertation" @default.
• W1981123857 hasAuthorship W1981123857A5016261020 @default.
• W1981123857 hasConcept C11960822 @default.
• W1981123857 hasConcept C126322002 @default.
• W1981123857 hasConcept C185592680 @default.
• W1981123857 hasConcept C207200792 @default.
• W1981123857 hasConcept C2776151105 @default.
• W1981123857 hasConcept C2777192995 @default.
• W1981123857 hasConcept C2778004101 @default.
• W1981123857 hasConcept C2908647359 @default.
• W1981123857 hasConcept C55493867 @default.
• W1981123857 hasConcept C57074206 @default.
• W1981123857 hasConcept C70899900 @default.
• W1981123857 hasConcept C71924100 @default.
• W1981123857 hasConcept C98274493 @default.
• W1981123857 hasConcept C99454951 @default.
• W1981123857 hasConceptScore W1981123857C11960822 @default.
• W1981123857 hasConceptScore W1981123857C126322002 @default.
• W1981123857 hasConceptScore W1981123857C185592680 @default.
• W1981123857 hasConceptScore W1981123857C207200792 @default.
• W1981123857 hasConceptScore W1981123857C2776151105 @default.
• W1981123857 hasConceptScore W1981123857C2777192995 @default.
• W1981123857 hasConceptScore W1981123857C2778004101 @default.
• W1981123857 hasConceptScore W1981123857C2908647359 @default.
• W1981123857 hasConceptScore W1981123857C55493867 @default.
• W1981123857 hasConceptScore W1981123857C57074206 @default.
• W1981123857 hasConceptScore W1981123857C70899900 @default.
• W1981123857 hasConceptScore W1981123857C71924100 @default.
• W1981123857 hasConceptScore W1981123857C98274493 @default.
• W1981123857 hasConceptScore W1981123857C99454951 @default.
• W1981123857 hasLocation W19811238571 @default.
• W1981123857 hasOpenAccess W1981123857 @default.
• W1981123857 hasPrimaryLocation W19811238571 @default.
• W1981123857 hasRelatedWork W1979414483 @default.
• W1981123857 hasRelatedWork W1987564143 @default.
• W1981123857 hasRelatedWork W2005151269 @default.
• W1981123857 hasRelatedWork W2007428734 @default.
• W1981123857 hasRelatedWork W2012489234 @default.
• W1981123857 hasRelatedWork W2031070839 @default.
• W1981123857 hasRelatedWork W2048130918 @default.
• W1981123857 hasRelatedWork W2048604212 @default.
• W1981123857 hasRelatedWork W2056755202 @default.
• W1981123857 hasRelatedWork W2125552828 @default.
• W1981123857 hasRelatedWork W2346930074 @default.
• W1981123857 hasRelatedWork W2803169848 @default.
• W1981123857 hasRelatedWork W2904104631 @default.
• W1981123857 hasRelatedWork W2923445574 @default.
• W1981123857 hasRelatedWork W2966907977 @default.
• W1981123857 hasRelatedWork W3027689569 @default.
• W1981123857 hasRelatedWork W3039473905 @default.
• W1981123857 hasRelatedWork W3131262417 @default.
• W1981123857 hasRelatedWork W3169471739 @default.
• W1981123857 hasRelatedWork W2602784089 @default.
• W1981123857 isParatext "false" @default.
• W1981123857 isRetracted "false" @default.
• W1981123857 magId "1981123857" @default.
• W1981123857 workType "dissertation" @default.