Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981124323> ?p ?o ?g. }
- W1981124323 endingPage "1084" @default.
- W1981124323 startingPage "d1072" @default.
- W1981124323 abstract "Glucose transport across the cell surface is a key regulatory step for glucose metabolism in skeletal muscle. Both insulin and exercise increase glucose transport into myofibers through glucose transporter (GLUT) proteins. Skeletal muscle expresses several members of the GLUT family but the GLUT4 glucose transporter is considered the main regulatable isoform that is modulated by insulin and contraction. Glucose transport rate can be stimulated either by recruitment of GLUT4 units from intracellular storage vesicles or through activation of cell surface transporters. Insulin activates GLUT4 translocation through a complex signaling cascade involving both the lipid kinase phosphatidylinositol 3-kinase and the proto-oncoprotein c-Cbl. Contraction, on the other hand, appears to trigger GLUT4 translocation at least in part through activation of the metabolite-sensing 5'-AMP-activated protein kinase. Furthermore, recent studies suggest that p38 MAP kinase activation represents a point of convergence of the signaling pathways utilized by insulin and contraction to increase GLUT4 activation at the cell surface. This review will summarize our current knowledge of these alternative pathways of GLUT4 regulation in skeletal muscle." @default.
- W1981124323 created "2016-06-24" @default.
- W1981124323 creator A5007768979 @default.
- W1981124323 creator A5015147651 @default.
- W1981124323 creator A5060937292 @default.
- W1981124323 date "2003-01-01" @default.
- W1981124323 modified "2023-09-23" @default.
- W1981124323 title "Regulation of GLUT4 traffic and function by insulin and contraction in skeletal muscle" @default.
- W1981124323 cites W1482754145 @default.
- W1981124323 cites W1485156902 @default.
- W1981124323 cites W1506981847 @default.
- W1981124323 cites W1545244782 @default.
- W1981124323 cites W1559230807 @default.
- W1981124323 cites W1571455007 @default.
- W1981124323 cites W1625152287 @default.
- W1981124323 cites W1726652071 @default.
- W1981124323 cites W1788773694 @default.
- W1981124323 cites W1809671836 @default.
- W1981124323 cites W1820085648 @default.
- W1981124323 cites W1841050729 @default.
- W1981124323 cites W1857724021 @default.
- W1981124323 cites W1911968642 @default.
- W1981124323 cites W1931082872 @default.
- W1981124323 cites W1964606633 @default.
- W1981124323 cites W1972078981 @default.
- W1981124323 cites W1972307668 @default.
- W1981124323 cites W1976177239 @default.
- W1981124323 cites W1976261899 @default.
- W1981124323 cites W1976494080 @default.
- W1981124323 cites W1978963285 @default.
- W1981124323 cites W1979365820 @default.
- W1981124323 cites W1983927973 @default.
- W1981124323 cites W1988243311 @default.
- W1981124323 cites W1989245013 @default.
- W1981124323 cites W1993429838 @default.
- W1981124323 cites W1995265367 @default.
- W1981124323 cites W1995831169 @default.
- W1981124323 cites W1995950951 @default.
- W1981124323 cites W1997460544 @default.
- W1981124323 cites W1997862023 @default.
- W1981124323 cites W1999123584 @default.
- W1981124323 cites W2003045046 @default.
- W1981124323 cites W2004767178 @default.
- W1981124323 cites W2005214072 @default.
- W1981124323 cites W2007089466 @default.
- W1981124323 cites W2009181620 @default.
- W1981124323 cites W2010763118 @default.
- W1981124323 cites W2011010005 @default.
- W1981124323 cites W2012116123 @default.
- W1981124323 cites W2018973416 @default.
- W1981124323 cites W2025208478 @default.
- W1981124323 cites W2026470317 @default.
- W1981124323 cites W2030720692 @default.
- W1981124323 cites W2031532881 @default.
- W1981124323 cites W2032227852 @default.
- W1981124323 cites W2033575261 @default.
- W1981124323 cites W2033860501 @default.
- W1981124323 cites W2036040491 @default.
- W1981124323 cites W2039193709 @default.
- W1981124323 cites W2044455015 @default.
- W1981124323 cites W2045984022 @default.
- W1981124323 cites W2046147374 @default.
- W1981124323 cites W2046525768 @default.
- W1981124323 cites W2067522487 @default.
- W1981124323 cites W2067854585 @default.
- W1981124323 cites W2068820862 @default.
- W1981124323 cites W2071737894 @default.
- W1981124323 cites W2077230920 @default.
- W1981124323 cites W2088702765 @default.
- W1981124323 cites W2094338116 @default.
- W1981124323 cites W2096182335 @default.
- W1981124323 cites W2096441744 @default.
- W1981124323 cites W2101400542 @default.
- W1981124323 cites W2101994325 @default.
- W1981124323 cites W2103436972 @default.
- W1981124323 cites W2104847030 @default.
- W1981124323 cites W2105769212 @default.
- W1981124323 cites W2106563675 @default.
- W1981124323 cites W2111081715 @default.
- W1981124323 cites W2111158723 @default.
- W1981124323 cites W2114419351 @default.
- W1981124323 cites W2115569175 @default.
- W1981124323 cites W2116195267 @default.
- W1981124323 cites W2116803850 @default.
- W1981124323 cites W2120741506 @default.
- W1981124323 cites W2120753520 @default.
- W1981124323 cites W2124311814 @default.
- W1981124323 cites W2124536446 @default.
- W1981124323 cites W2126317966 @default.
- W1981124323 cites W2128258266 @default.
- W1981124323 cites W2129778537 @default.
- W1981124323 cites W2132666492 @default.
- W1981124323 cites W2133374963 @default.
- W1981124323 cites W2133790985 @default.
- W1981124323 cites W2135704900 @default.
- W1981124323 cites W2135932038 @default.
- W1981124323 cites W2137558221 @default.
- W1981124323 cites W2139648742 @default.