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• W1981124682 abstract "F1-ATPase is an ATP-driven rotary molecular motor that synthesizes ATP when rotated in reverse. To elucidate the mechanism of ATP synthesis, we imaged binding and release of fluorescently labelled ADP and ATP while rotating the motor in either direction by magnets. Here we report the binding and release rates for each of the three catalytic sites for 360° of the rotary angle. We show that the rates do not significantly depend on the rotary direction, indicating ATP synthesis by direct reversal of the hydrolysis-driven rotation. ADP and ATP are discriminated in angle-dependent binding, but not in release. Phosphate blocks ATP binding at angles where ADP binding is essential for ATP synthesis. In synthesis rotation, the affinity for ADP increases by >104, followed by a shift to high ATP affinity, and finally the affinity for ATP decreases by >104. All these angular changes are gradual, implicating tight coupling between the rotor angle and site affinities. Reverse rotation of the F1-ATPase results in the synthesis, rather than hydrolysis of ATP. Adachiet al. show that the molecular mechanism of ATP synthesis is the reverse of hydrolysis-driven rotation of the motor, and that ADP and ATP are discriminated by angle-dependent binding." @default.
• W1981124682 created "2016-06-24" @default.
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• W1981124682 date "2012-08-28" @default.
• W1981124682 modified "2023-09-28" @default.
• W1981124682 title "Controlled rotation of the F1-ATPase reveals differential and continuous binding changes for ATP synthesis" @default.
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• W1981124682 doi "https://doi.org/10.1038/ncomms2026" @default.
• W1981124682 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3449090" @default.
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