Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981125871> ?p ?o ?g. }
- W1981125871 endingPage "e35144" @default.
- W1981125871 startingPage "e35144" @default.
- W1981125871 abstract "Interleukin-6 (IL-6) is an important cytokine participating in multiple biologic activities in immune regulation and inflammation. IL-6 has been associated with cardiovascular remodeling. However, the mechanism of IL-6 in hypertensive cardiac fibrosis is still unclear. Angiotensin II (Ang II) infusion in mice increased IL-6 expression in the heart. IL-6 knockout (IL-6-/-) reduced Ang II-induced cardiac fibrosis: 1) Masson trichrome staining showed that Ang II infusion significantly increased fibrotic areas of the wild-type mouse heart, which was greatly suppressed in IL-6-/- mice and 2) immunohistochemistry staining showed decreased expression of α-smooth muscle actin (α-SMA), transforming growth factor β1 (TGF-β1) and collagen I in IL-6-/- mouse heart. The baseline mRNA expression of IL-6 in cardiac fibroblasts was low and was absent in cardiomyocytes or macrophages; however, co-culture of cardiac fibroblasts with macrophages significantly increased IL-6 production and expression of α-SMA and collagen I in fibroblasts. Moreover, TGF-β1 expression and phosphorylation of TGF-β downstream signal Smad3 was stimulated by co-culture of macrophages with cardiac fibroblasts, while IL-6 neutralizing antibody decreased TGF-β1 expression and Smad3 phosphorylation in co-culture of macrophage and fibroblast. Taken together, our results indicate that macrophages stimulate cardiac fibroblasts to produce IL-6, which leads to TGF-β1 production and Smad3 phosphorylation in cardiac fibroblasts and thus stimulates cardiac fibrosis." @default.
- W1981125871 created "2016-06-24" @default.
- W1981125871 creator A5000395076 @default.
- W1981125871 creator A5002858967 @default.
- W1981125871 creator A5021848650 @default.
- W1981125871 creator A5031524039 @default.
- W1981125871 creator A5035978001 @default.
- W1981125871 creator A5058814917 @default.
- W1981125871 creator A5059317683 @default.
- W1981125871 creator A5083423037 @default.
- W1981125871 date "2012-05-04" @default.
- W1981125871 modified "2023-10-16" @default.
- W1981125871 title "Macrophage-Stimulated Cardiac Fibroblast Production of IL-6 Is Essential for TGF β/Smad Activation and Cardiac Fibrosis Induced by Angiotensin II" @default.
- W1981125871 cites W1575754639 @default.
- W1981125871 cites W1809966404 @default.
- W1981125871 cites W1942404831 @default.
- W1981125871 cites W1974159422 @default.
- W1981125871 cites W1994915655 @default.
- W1981125871 cites W1996514275 @default.
- W1981125871 cites W2002329380 @default.
- W1981125871 cites W2004589191 @default.
- W1981125871 cites W2006738388 @default.
- W1981125871 cites W2020393169 @default.
- W1981125871 cites W2020815627 @default.
- W1981125871 cites W2023278759 @default.
- W1981125871 cites W2029654767 @default.
- W1981125871 cites W2043659211 @default.
- W1981125871 cites W2045064645 @default.
- W1981125871 cites W2050753692 @default.
- W1981125871 cites W2058113350 @default.
- W1981125871 cites W2091549444 @default.
- W1981125871 cites W2094848681 @default.
- W1981125871 cites W2101922329 @default.
- W1981125871 cites W2116091611 @default.
- W1981125871 cites W2117205119 @default.
- W1981125871 cites W2120707690 @default.
- W1981125871 cites W2126816808 @default.
- W1981125871 cites W2129043350 @default.
- W1981125871 cites W2135401778 @default.
- W1981125871 cites W2147758809 @default.
- W1981125871 cites W2153538485 @default.
- W1981125871 cites W2159753941 @default.
- W1981125871 cites W2160579895 @default.
- W1981125871 cites W2161197757 @default.
- W1981125871 cites W2163295962 @default.
- W1981125871 cites W2164171309 @default.
- W1981125871 cites W2165334726 @default.
- W1981125871 cites W2167731943 @default.
- W1981125871 cites W2169970431 @default.
- W1981125871 doi "https://doi.org/10.1371/journal.pone.0035144" @default.
- W1981125871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3344835" @default.
- W1981125871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22574112" @default.
- W1981125871 hasPublicationYear "2012" @default.
- W1981125871 type Work @default.
- W1981125871 sameAs 1981125871 @default.
- W1981125871 citedByCount "201" @default.
- W1981125871 countsByYear W19811258712012 @default.
- W1981125871 countsByYear W19811258712013 @default.
- W1981125871 countsByYear W19811258712014 @default.
- W1981125871 countsByYear W19811258712015 @default.
- W1981125871 countsByYear W19811258712016 @default.
- W1981125871 countsByYear W19811258712017 @default.
- W1981125871 countsByYear W19811258712018 @default.
- W1981125871 countsByYear W19811258712019 @default.
- W1981125871 countsByYear W19811258712020 @default.
- W1981125871 countsByYear W19811258712021 @default.
- W1981125871 countsByYear W19811258712022 @default.
- W1981125871 countsByYear W19811258712023 @default.
- W1981125871 crossrefType "journal-article" @default.
- W1981125871 hasAuthorship W1981125871A5000395076 @default.
- W1981125871 hasAuthorship W1981125871A5002858967 @default.
- W1981125871 hasAuthorship W1981125871A5021848650 @default.
- W1981125871 hasAuthorship W1981125871A5031524039 @default.
- W1981125871 hasAuthorship W1981125871A5035978001 @default.
- W1981125871 hasAuthorship W1981125871A5058814917 @default.
- W1981125871 hasAuthorship W1981125871A5059317683 @default.
- W1981125871 hasAuthorship W1981125871A5083423037 @default.
- W1981125871 hasBestOaLocation W19811258711 @default.
- W1981125871 hasConcept C118131993 @default.
- W1981125871 hasConcept C126322002 @default.
- W1981125871 hasConcept C134018914 @default.
- W1981125871 hasConcept C170493617 @default.
- W1981125871 hasConcept C185592680 @default.
- W1981125871 hasConcept C202751555 @default.
- W1981125871 hasConcept C2777420927 @default.
- W1981125871 hasConcept C2778690821 @default.
- W1981125871 hasConcept C2779244956 @default.
- W1981125871 hasConcept C2780381497 @default.
- W1981125871 hasConcept C2780559512 @default.
- W1981125871 hasConcept C2781080636 @default.
- W1981125871 hasConcept C2908929049 @default.
- W1981125871 hasConcept C3018763269 @default.
- W1981125871 hasConcept C54355233 @default.
- W1981125871 hasConcept C55493867 @default.
- W1981125871 hasConcept C71924100 @default.
- W1981125871 hasConcept C81885089 @default.
- W1981125871 hasConcept C86803240 @default.
- W1981125871 hasConceptScore W1981125871C118131993 @default.