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• W1981126246 endingPage "E760" @default.
• W1981126246 startingPage "E752" @default.
• W1981126246 abstract "The aims of this investigation were to evaluate the effect of an amino acid supplement on the glucose response to an oral glucose challenge ( experiment 1) and to evaluate whether differences in blood glucose response were associated with increased skeletal muscle glucose uptake ( experimental 2). Experiment 1 rats were gavaged with either glucose (CHO), glucose plus an amino acid mixture (CHO-AA-1), glucose plus an amino acid mixture with increased leucine concentration (CHO-AA-2), or water (PLA). CHO-AA-1 and CHO-AA-2 had reduced blood glucose responses compared with CHO, with no difference in insulin among these treatments. Experiment 2 rats were gavaged with either CHO or CHO-AA-1. Fifteen minutes after gavage, a bolus containing 2-[ 3 H]deoxyglucose and [U- 14 C]mannitol was infused via a tail vein. Blood glucose was significantly lower in CHO-AA-1 than in CHO, whereas insulin responses were similar. Muscle glucose uptake was higher in CHO-AA-1 compared with CHO in both fast-twitch red (8.36 ± 1.3 vs. 5.27 ± 0.7 μmol·g −1 ·h −1 ) and white muscle (1.85 ± 0.3 vs. 1.11 ± 0.2 μmol·g −1 ·h −1 ). There was no difference in Akt/PKB phosphorylation between treatment groups; however, the amino acid treatment resulted in increased AS160 phosphorylation in both muscle fiber types. Glycogen synthase phosphorylation was reduced in fast-twitch red muscle of CHO-AA-1 compared with CHO, whereas mTOR phosphorylation was increased. These differences were not noted in fast-twitch white muscle. These findings suggest that amino acid supplementation can improve glucose tolerance by increasing skeletal muscle glucose uptake and intracellular disposal through enhanced intracellular signaling." @default.
• W1981126246 created "2016-06-24" @default.
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• W1981126246 date "2011-04-01" @default.
• W1981126246 modified "2023-10-16" @default.
• W1981126246 title "An amino acid mixture improves glucose tolerance and insulin signaling in Sprague-Dawley rats" @default.
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• W1981126246 doi "https://doi.org/10.1152/ajpendo.00643.2010" @default.
• W1981126246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21304065" @default.
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