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• W1981127575 abstract "Purpose: CT, MR and SPECT / PET data can offer important information in diagnosis, treatment and follow-up of tumors. While various methods of fusing CT and MRI have been developed and offer satisfactory results, the possibility of assigning functional information of lower resolution - SPECT/PET images to precisely defined anatomical structures remains a challenge. We present the relevance for radiotherapy of a simple, reliable, precise and non-invasive method of combining functional and anatomical modalities on a case report of a 52 year old woman with optic nerve meningeoma. Materials and Methods: 3D dataset acquisition is performed with a reference frame (SIPLab Innsbruck Frame) with 11 modality-specific markers in precisely defined positions. This frame is reproducibly connected to the Vogele Bale Hohner (VBH) vacuum- mouthpiece, which allows objectively identical repositioning of the frame with respect to the head (Fig.1). The desired 3D imaging modalities can then be manually (SPECT-CT/MR:paired-point matching) or automatically (CT/MR:voxel based) fused using commercially available planning software (Zmed; Framelink). The same vacuum MP can be used for reproducible head fixation during treatment. Results: 21 patients have been treated and followed using the above method, the fusion was deemed to increase the confidence in the functional information considerably and in 11 cases the functional information was clinically relevant. As an indicator of registration accuracy, the RMSE (root mean square error) of all 117 datsets registered via the external landmarks was 0.9 mm for CT-MR and 1.4 mm for SPECT-CT fusion. No measurable deviations occurred in automatically merged CT/MR datasets unless head position in the respective scanners differed greatly, requiring use of external markers for registration. Fusion per data-pair requires <5 minutes. A representative pictorial case report of a 56 year old female with optic meningeoma, whose loss of functional activity (SPECT) of the tumor after 50 Gy XRT corresponded with an impressive recovery of eyesight, is presented. Activity in the parasagittal frontal region with no CT/MRI correlate remains in observance during follow-up. Conclusion: This method is a simple and accurate tool to combine 3D diagnosis, treatment planning, treatment and follow-up (as fourth dimension), all via a vacuum mouthpiece. In the scope of a unified approach in the treatment of cranial tumors at this institution, the same vacuum-MP and frame are used for frameless stereotactic biopsy and neurosurgery in select cases." @default.
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• W1981127575 date "2001-11-01" @default.
• W1981127575 modified "2023-09-27" @default.
• W1981127575 title "CT-MR-SPECT Fusion based on a vacuum-dental frame and its application in radiotherapy - planning, treatment and follow-up" @default.
• W1981127575 doi "https://doi.org/10.1016/s0360-3016(01)02146-0" @default.
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