Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981137192> ?p ?o ?g. }
- W1981137192 endingPage "37" @default.
- W1981137192 startingPage "30" @default.
- W1981137192 abstract "Summary Human invariant natural killer (iNK) T cells expressing an invariant Vα24‐Jα15 T‐cell receptor (TCR) are thought to be important regulators of autoimmunity and tumour surveillance. Two major subsets of iNK T cells, CD4 + or CD4 − CD8 − are known to exist, but the in vivo importance of CD4 expression is unclear. Since interleukin‐12 (IL‐12) is a key iNK T‐cell‐activating cytokine, the effect of IL‐12 plus or minus the T‐cell growth factor IL‐2 on a large panel of CD4 + versus CD4 − CD8 − iNK T‐cell clones was examined. Strikingly, IL‐12 and IL‐2 significantly activated iNK T cells to secrete IL‐4, interferon‐γ and granulocyte–macrophage colony‐stimulating factor, and up‐regulated perforin expression in the absence of TCR stimulation. Furthermore, IL‐2 and IL‐12 treatment resulted in a preferential increase in apoptosis of CD4 − CD8 − clones. Thus, independent of TCR activation, IL‐2 and IL‐12 can directly activate iNK T cells and provide a selective advantage to the CD4 + iNK T‐cell population." @default.
- W1981137192 created "2016-06-24" @default.
- W1981137192 creator A5003947352 @default.
- W1981137192 creator A5012068082 @default.
- W1981137192 creator A5037391809 @default.
- W1981137192 creator A5040129865 @default.
- W1981137192 creator A5045190332 @default.
- W1981137192 date "2003-08-22" @default.
- W1981137192 modified "2023-10-15" @default.
- W1981137192 title "Interleukin-12 and interleukin-2-induced invariant natural killer T-cell cytokine secretion and perforin expression independent of T-cell receptor activation" @default.
- W1981137192 cites W1498090319 @default.
- W1981137192 cites W1515742692 @default.
- W1981137192 cites W1516048300 @default.
- W1981137192 cites W1522949210 @default.
- W1981137192 cites W1523753658 @default.
- W1981137192 cites W1545910465 @default.
- W1981137192 cites W1594342761 @default.
- W1981137192 cites W1595465958 @default.
- W1981137192 cites W1600526298 @default.
- W1981137192 cites W1601925808 @default.
- W1981137192 cites W1610828262 @default.
- W1981137192 cites W1799419298 @default.
- W1981137192 cites W1838853754 @default.
- W1981137192 cites W1856377922 @default.
- W1981137192 cites W1894308601 @default.
- W1981137192 cites W1925645192 @default.
- W1981137192 cites W1931343305 @default.
- W1981137192 cites W1945740511 @default.
- W1981137192 cites W1973040027 @default.
- W1981137192 cites W1979514172 @default.
- W1981137192 cites W1979727939 @default.
- W1981137192 cites W1981296364 @default.
- W1981137192 cites W1985029921 @default.
- W1981137192 cites W1991524518 @default.
- W1981137192 cites W1992318576 @default.
- W1981137192 cites W1995529916 @default.
- W1981137192 cites W1996030543 @default.
- W1981137192 cites W2005543808 @default.
- W1981137192 cites W2008446420 @default.
- W1981137192 cites W2014582730 @default.
- W1981137192 cites W2016362082 @default.
- W1981137192 cites W2025795383 @default.
- W1981137192 cites W2036504193 @default.
- W1981137192 cites W2055971070 @default.
- W1981137192 cites W2065709904 @default.
- W1981137192 cites W2069102137 @default.
- W1981137192 cites W2069929656 @default.
- W1981137192 cites W2074843663 @default.
- W1981137192 cites W2075644230 @default.
- W1981137192 cites W2077971102 @default.
- W1981137192 cites W2102156468 @default.
- W1981137192 cites W2104899797 @default.
- W1981137192 cites W2111935751 @default.
- W1981137192 cites W2130295685 @default.
- W1981137192 cites W2132363654 @default.
- W1981137192 cites W2140283761 @default.
- W1981137192 cites W2148259690 @default.
- W1981137192 cites W2153552716 @default.
- W1981137192 cites W2157278565 @default.
- W1981137192 cites W2159312193 @default.
- W1981137192 cites W2161307276 @default.
- W1981137192 cites W2161916137 @default.
- W1981137192 cites W2163466184 @default.
- W1981137192 cites W2167094013 @default.
- W1981137192 cites W2168892798 @default.
- W1981137192 cites W2170417753 @default.
- W1981137192 cites W2171356028 @default.
- W1981137192 cites W2186514471 @default.
- W1981137192 cites W4206439534 @default.
- W1981137192 cites W4313335817 @default.
- W1981137192 cites W4313379151 @default.
- W1981137192 doi "https://doi.org/10.1046/j.1365-2567.2003.01701.x" @default.
- W1981137192 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1783023" @default.
- W1981137192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12941138" @default.
- W1981137192 hasPublicationYear "2003" @default.
- W1981137192 type Work @default.
- W1981137192 sameAs 1981137192 @default.
- W1981137192 citedByCount "21" @default.
- W1981137192 countsByYear W19811371922014 @default.
- W1981137192 countsByYear W19811371922016 @default.
- W1981137192 countsByYear W19811371922017 @default.
- W1981137192 countsByYear W19811371922018 @default.
- W1981137192 countsByYear W19811371922019 @default.
- W1981137192 countsByYear W19811371922021 @default.
- W1981137192 countsByYear W19811371922023 @default.
- W1981137192 crossrefType "journal-article" @default.
- W1981137192 hasAuthorship W1981137192A5003947352 @default.
- W1981137192 hasAuthorship W1981137192A5012068082 @default.
- W1981137192 hasAuthorship W1981137192A5037391809 @default.
- W1981137192 hasAuthorship W1981137192A5040129865 @default.
- W1981137192 hasAuthorship W1981137192A5045190332 @default.
- W1981137192 hasBestOaLocation W19811371921 @default.
- W1981137192 hasConcept C129374314 @default.
- W1981137192 hasConcept C131665280 @default.
- W1981137192 hasConcept C139563560 @default.
- W1981137192 hasConcept C149532602 @default.
- W1981137192 hasConcept C154317977 @default.
- W1981137192 hasConcept C167672396 @default.