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- W1981149494 endingPage "1535" @default.
- W1981149494 startingPage "1522" @default.
- W1981149494 abstract "Worldwide, nearly 1.7 billion people per year contract diarrheal infectious diseases (DID) and almost 760 000 of infections are fatal. DID are a major problem in developing countries where poor sanitation prevails and food and water may become contaminated by fecal shedding. Diarrhea is caused by pathogens such as bacteria, protozoans and viruses. Important diarrheal pathogens are Vibrio cholerae, Shigella spp. and rotavirus, which can be prevented with vaccines for several years. The focus of this review is on currently available vaccines against these three pathogens, and on development of new vaccines. Currently, various types of vaccines based on traditional (killed, live attenuated, toxoid or conjugate vaccines) and reverse vaccinology (DNA/mRNA, vector, recombinant subunit, plant vaccines) are in development or already available. Development of new vaccines demands high levels of knowledge, experience, budget, and time, yet promising new vaccines often fail in preclinical and clinical studies. Efficacy of vaccination also depends on the route of delivery, and mucosal immunization in particular is of special interest for preventing DID. Furthermore, adjuvants, delivery systems and other vaccine components are essential for an adequate immune response. These aspects will be discussed in relation to the improvement of existing and development of new vaccines against DID." @default.
- W1981149494 created "2016-06-24" @default.
- W1981149494 creator A5061209530 @default.
- W1981149494 creator A5061769593 @default.
- W1981149494 creator A5088786843 @default.
- W1981149494 date "2014-05-26" @default.
- W1981149494 modified "2023-10-17" @default.
- W1981149494 title "Vaccines against human diarrheal pathogens" @default.
- W1981149494 cites W1515176596 @default.
- W1981149494 cites W1553308524 @default.
- W1981149494 cites W1637418879 @default.
- W1981149494 cites W1797014195 @default.
- W1981149494 cites W181453810 @default.
- W1981149494 cites W1903406597 @default.
- W1981149494 cites W1939990278 @default.
- W1981149494 cites W1964020301 @default.
- W1981149494 cites W1966142962 @default.
- W1981149494 cites W1967343781 @default.
- W1981149494 cites W1971112216 @default.
- W1981149494 cites W1973775956 @default.
- W1981149494 cites W1977101213 @default.
- W1981149494 cites W1980670391 @default.
- W1981149494 cites W1981017662 @default.
- W1981149494 cites W1982279452 @default.
- W1981149494 cites W1983206455 @default.
- W1981149494 cites W1983514420 @default.
- W1981149494 cites W1985718027 @default.
- W1981149494 cites W1988826296 @default.
- W1981149494 cites W1990954596 @default.
- W1981149494 cites W1992090962 @default.
- W1981149494 cites W1993434192 @default.
- W1981149494 cites W1993757904 @default.
- W1981149494 cites W1996786545 @default.
- W1981149494 cites W2002007480 @default.
- W1981149494 cites W2005181721 @default.
- W1981149494 cites W2006117243 @default.
- W1981149494 cites W2007923993 @default.
- W1981149494 cites W2013103459 @default.
- W1981149494 cites W2016286633 @default.
- W1981149494 cites W2018007825 @default.
- W1981149494 cites W2018271365 @default.
- W1981149494 cites W2021918725 @default.
- W1981149494 cites W2028722585 @default.
- W1981149494 cites W2035152237 @default.
- W1981149494 cites W2037368025 @default.
- W1981149494 cites W2037829353 @default.
- W1981149494 cites W2041898898 @default.
- W1981149494 cites W2042116577 @default.
- W1981149494 cites W2043101254 @default.
- W1981149494 cites W2043331724 @default.
- W1981149494 cites W2046397739 @default.
- W1981149494 cites W2046498003 @default.
- W1981149494 cites W2047915395 @default.
- W1981149494 cites W2050588393 @default.
- W1981149494 cites W2052010022 @default.
- W1981149494 cites W2057392926 @default.
- W1981149494 cites W2063694955 @default.
- W1981149494 cites W2068086750 @default.
- W1981149494 cites W2071475038 @default.
- W1981149494 cites W2072134413 @default.
- W1981149494 cites W2072433927 @default.
- W1981149494 cites W2072515610 @default.
- W1981149494 cites W2072881891 @default.
- W1981149494 cites W2072947245 @default.
- W1981149494 cites W2075380043 @default.
- W1981149494 cites W2076095839 @default.
- W1981149494 cites W2076402806 @default.
- W1981149494 cites W2076423932 @default.
- W1981149494 cites W2078495720 @default.
- W1981149494 cites W2084178215 @default.
- W1981149494 cites W2084480062 @default.
- W1981149494 cites W2091311753 @default.
- W1981149494 cites W2095451533 @default.
- W1981149494 cites W2101078682 @default.
- W1981149494 cites W2101893457 @default.
- W1981149494 cites W2106465368 @default.
- W1981149494 cites W2107362700 @default.
- W1981149494 cites W2109078302 @default.
- W1981149494 cites W2112992535 @default.
- W1981149494 cites W2115068933 @default.
- W1981149494 cites W2116056591 @default.
- W1981149494 cites W2116562647 @default.
- W1981149494 cites W2118004959 @default.
- W1981149494 cites W2118936437 @default.
- W1981149494 cites W2120936388 @default.
- W1981149494 cites W2123583824 @default.
- W1981149494 cites W2124672930 @default.
- W1981149494 cites W2124849592 @default.
- W1981149494 cites W2129891858 @default.
- W1981149494 cites W2130481574 @default.
- W1981149494 cites W2131001400 @default.
- W1981149494 cites W2131154800 @default.
- W1981149494 cites W2133623475 @default.
- W1981149494 cites W2136188247 @default.
- W1981149494 cites W2136547924 @default.
- W1981149494 cites W2137858178 @default.
- W1981149494 cites W2139295688 @default.
- W1981149494 cites W2140926423 @default.