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- W1981157515 abstract "Recent studies suggest that stage-independent symptoms of primary biliary cirrhosis (PBC) such as chronic fatigue are a consequence of structural and functional abnormalities of the brain. Critical flicker frequency (CFF) is a psychophysiological modality analysing function of cerebral cortex.To analyse the usefulness of CFF in detection of brain dysfunction in patients with PBC.Fifty-one (37 non-cirrhotic/14 cirrhotic) patients with PBC were included. Control group consisted of 31 matched healthy individuals. Fatigue and health-related quality of life (HRQoL) were assessed using Fatigue Impact Scale (FIS) and questionnaire PBC-40. CFF was analysed with HEPAtonorm Analyzer(®).When compared to healthy controls all patients with PBC showed significantly impaired HRQoL in majority of PBC-40 domains and increased fatigue level in physical domain of FIS. No differences in HRQoL and PBC-40 domains were seen, when patients with and without cirrhosis where compared. CFF analysis showed no difference between healthy controls and patients with PBC. CFF did not correlate with PBC-40 and FIS domains.CFF fails to determine brain dysfunction in non-encephalopatic patients with PBC, suggesting that functional efficiency of their cerebral cortex remains unaffected and other central mechanisms are responsible for chronic fatigue in these patients." @default.
- W1981157515 created "2016-06-24" @default.
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- W1981157515 date "2010-11-01" @default.
- W1981157515 modified "2023-09-28" @default.
- W1981157515 title "Critical flicker frequency fails to disclose brain dysfunction in patients with primary biliary cirrhosis" @default.
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- W1981157515 doi "https://doi.org/10.1016/j.dld.2010.03.017" @default.
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