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- W1981170019 abstract "The first vaccine against human hepatitis B virus was licensed for use in the United States in 1981 and became commercially available in 1982.1 The development of this vaccine represented a milestone in medicine and was the product of two decades of intensive research into the structure and biology of hepatitis B virus. The first vaccine consisted of particles of purified and inactivated hepatitis B surface antigen (HBsAg) extracted from pooled plasma from long-term carriers of HBsAg. A second milestone was reached in 1984 with the development of a recombinant hepatitis B vaccine, the first human vaccine produced with molecular . . ." @default.
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- W1981170019 date "1989-11-09" @default.
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- W1981170019 title "Toward Universal Vaccination against Hepatitis B Virus" @default.
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- W1981170019 doi "https://doi.org/10.1056/nejm198911093211910" @default.
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