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- W1981174545 abstract "S351 INTRODUCTION: Sevoflurane is a useful anesthetic for mask induction in children because of its low blood solubility and relative pleasant smell. Clonidine has sedative and anxiolytic properties and reduces the requirement for inhalation agents. Since the awaking concentration (MAC-awake) of sevoflurane in children has never been reported, we examined it. METHODS: Sixty-three patients, aged 2 to 10 yr, were randomly assigned one of three groups. They received no premedication (control, 2 [micro sign]g/kg (OTC-2 group) and 4 [micro sign]g/kg (OTC-4 group) of oral transmucosal clonidine OTC which made of the drug and candy matrix, respectively. Induction and maintenance of general anesthesia were obtained sevoflurane in oxygen. After the completion of surgery, end-tidal concentration of sevoflurane was decreased from 1.0%. Sevoflurane concentration was kept for 15 min and an investigator called the patient's name. If the patient failed to open his eyes, the end-tidal concentration was dfecreased by 0.2%, and the above process was repeated until the patient responded to call name. The concentration midway between the value permitting the response and that just preventing the response was defined as awaking concentration. RESULTS: There was no difference in patient's age, weight and height between the three groups (Table 1). The MAC-awake of sevoflurane were 0.78 +/- 0.02% (Mean +/- SE), 0.36 +/- 0.02% and 0.36 +/- 0.04% in control, OTC-2 and OTC-4 group, respectively. The MAC-awake values in OTC-2 and OTC-4 group were significantly less than control group, whereas no significant difference was seen in these variables between the OTC-2 and OTC-4 groups (Figure 1).Table 1: Demographic DataFigure 1: Awaking concentration of SevofluraneDISCUSSION: Oral transmucosal clonidine premedication with 2 [micro sign]g/kg and 4 [micro sign]g/kg reduced the MAC-awake of sevoflurane the same degree. Although this reason was not clear from this study, a ceiling effect of clonidine on the MAC-awake of sevoflurane was suspected." @default.
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- W1981174545 date "1999-02-01" @default.
- W1981174545 modified "2023-09-25" @default.
- W1981174545 title "ORAL TRANSMUCOSAL CLONIDINE PREMEDICATION REDUCES THE AWAKING CONCENTRATION (MAC-awake) OF SEVOFLURANE IN CHILDREN" @default.
- W1981174545 doi "https://doi.org/10.1097/00000539-199902001-00348" @default.
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