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• W1981183669 abstract "Nedd4 and Nedd4-2 are closely related HECT-type ubiquitin-protein ligases (E3) implicated in the regulation of a number of proteins and pathways. Given the close homology between these E3 enzymes it would be predicted that a conserved ubiquitin-conjugating enzyme (E2) specificity exists between the two proteins. However, E2 specificities for Nedd4 and Nedd4-2 are not well established. In the present studies we aimed at clarifying the E2-specificities of Nedd4 and Nedd4-2 using in vitro ubiquitination assays. We demonstrate strong substrate ubiquitination in the presence of UbcH5b by both Nedd4 and Nedd4-2. We also found that Ube2e3, an E2 previously shown to be used by Nedd4-2, is used less efficiently than UbcH5b. Our results suggest that for optimal ubiquitination Nedd4 and Nedd4-2 require the same E2 enzymes." @default.
• W1981183669 created "2016-06-24" @default.
• W1981183669 creator A5018098557 @default.
• W1981183669 creator A5063747716 @default.
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• W1981183669 date "2006-03-01" @default.
• W1981183669 modified "2023-09-26" @default.
• W1981183669 title "The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities" @default.
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• W1981183669 doi "https://doi.org/10.1016/j.biocel.2005.11.006" @default.
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