FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981190227> ?p ?o ?g. }

• W1981190227 endingPage "581" @default.
• W1981190227 startingPage "571" @default.
• W1981190227 abstract "Manganese superoxide dismutase (Mn-SOD, SOD2) is an inducible antioxidant localized to the mitochondria, which have been shown to be both the sites of superoxide anion (O2.-) production and the target of free radical attacks. Knock-out mice with targeted disruption of Sod2 (SOD2-KO) are more susceptible to ischemic damage than their wild-type (WT) counterparts, showing increased loss of mitochondrial cytochrome c after trauma, but less apoptotic cell death in the first 24 h following controlled cortical injury. In this study, we sought to investigate whether oxidative stress plays a significant role in the development of secondary brain damage following cold injury-induced brain trauma (CIBT), a model of vasogenic edema. We first measured the levels of O2.- production 2 h after CIBT by means of in situ hydroethidine oxidation. We then examined lesion size, brain swelling, apoptosis by morphology and TUNEL-staining, neutrophil infiltration, and hemorrhage rates in both SOD2-KO and WT mice at 1, 3, and 7 days post-CIBT. We found no significant differences between SOD2-KO and WT littermates in any of the paradigms or endpoints studied. There was, however, a significant increase in hemorrhagic transformations in all animals that paralleled a robust inflammatory response at 3 days post insult compared with the 24-h endpoint. In the CIBT model used in this study, a 50% reduction in SOD2 activity did not appear to alter the injury response, suggesting that accumulation of free radicals does not play a significant role in secondary brain damage as previously thought with this particular model." @default.
• W1981190227 created "2016-06-24" @default.
• W1981190227 creator A5013829313 @default.
• W1981190227 creator A5064877656 @default.
• W1981190227 creator A5073936292 @default.
• W1981190227 date "2003-06-01" @default.
• W1981190227 modified "2023-09-23" @default.
• W1981190227 title "Effects of Cold Injury–Induced Trauma in Manganese Superoxide Dismutase–Deficient Mice" @default.
• W1981190227 cites W1635047156 @default.
• W1981190227 cites W1666499734 @default.
• W1981190227 cites W1969195611 @default.
• W1981190227 cites W1985736394 @default.
• W1981190227 cites W1992975079 @default.
• W1981190227 cites W2010362434 @default.
• W1981190227 cites W2017381726 @default.
• W1981190227 cites W2017392776 @default.
• W1981190227 cites W2020569812 @default.
• W1981190227 cites W2036965165 @default.
• W1981190227 cites W2046076168 @default.
• W1981190227 cites W2050638637 @default.
• W1981190227 cites W2058121143 @default.
• W1981190227 cites W2059982861 @default.
• W1981190227 cites W2062754118 @default.
• W1981190227 cites W2067624621 @default.
• W1981190227 cites W2072554359 @default.
• W1981190227 cites W2081354810 @default.
• W1981190227 cites W2085126325 @default.
• W1981190227 cites W2090544950 @default.
• W1981190227 cites W2123619121 @default.
• W1981190227 cites W2131150967 @default.
• W1981190227 cites W2138116386 @default.
• W1981190227 cites W2139323441 @default.
• W1981190227 cites W2149967205 @default.
• W1981190227 cites W2154439380 @default.
• W1981190227 cites W2158799442 @default.
• W1981190227 cites W2442327564 @default.
• W1981190227 doi "https://doi.org/10.1089/089771503767168492" @default.
• W1981190227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12906741" @default.
• W1981190227 hasPublicationYear "2003" @default.
• W1981190227 type Work @default.
• W1981190227 sameAs 1981190227 @default.
• W1981190227 citedByCount "5" @default.
• W1981190227 countsByYear W19811902272012 @default.
• W1981190227 crossrefType "journal-article" @default.
• W1981190227 hasAuthorship W1981190227A5013829313 @default.
• W1981190227 hasAuthorship W1981190227A5064877656 @default.
• W1981190227 hasAuthorship W1981190227A5073936292 @default.
• W1981190227 hasConcept C126322002 @default.
• W1981190227 hasConcept C134018914 @default.
• W1981190227 hasConcept C142724271 @default.
• W1981190227 hasConcept C181199279 @default.
• W1981190227 hasConcept C185592680 @default.
• W1981190227 hasConcept C190283241 @default.
• W1981190227 hasConcept C196795494 @default.
• W1981190227 hasConcept C2775838275 @default.
• W1981190227 hasConcept C2776108821 @default.
• W1981190227 hasConcept C2776151105 @default.
• W1981190227 hasConcept C2777615887 @default.
• W1981190227 hasConcept C2780795997 @default.
• W1981190227 hasConcept C2780886150 @default.
• W1981190227 hasConcept C29311851 @default.
• W1981190227 hasConcept C48349386 @default.
• W1981190227 hasConcept C55493867 @default.
• W1981190227 hasConcept C71924100 @default.
• W1981190227 hasConceptScore W1981190227C126322002 @default.
• W1981190227 hasConceptScore W1981190227C134018914 @default.
• W1981190227 hasConceptScore W1981190227C142724271 @default.
• W1981190227 hasConceptScore W1981190227C181199279 @default.
• W1981190227 hasConceptScore W1981190227C185592680 @default.
• W1981190227 hasConceptScore W1981190227C190283241 @default.
• W1981190227 hasConceptScore W1981190227C196795494 @default.
• W1981190227 hasConceptScore W1981190227C2775838275 @default.
• W1981190227 hasConceptScore W1981190227C2776108821 @default.
• W1981190227 hasConceptScore W1981190227C2776151105 @default.
• W1981190227 hasConceptScore W1981190227C2777615887 @default.
• W1981190227 hasConceptScore W1981190227C2780795997 @default.
• W1981190227 hasConceptScore W1981190227C2780886150 @default.
• W1981190227 hasConceptScore W1981190227C29311851 @default.
• W1981190227 hasConceptScore W1981190227C48349386 @default.
• W1981190227 hasConceptScore W1981190227C55493867 @default.
• W1981190227 hasConceptScore W1981190227C71924100 @default.
• W1981190227 hasIssue "6" @default.
• W1981190227 hasLocation W19811902271 @default.
• W1981190227 hasLocation W19811902272 @default.
• W1981190227 hasOpenAccess W1981190227 @default.
• W1981190227 hasPrimaryLocation W19811902271 @default.
• W1981190227 hasRelatedWork W1759734542 @default.
• W1981190227 hasRelatedWork W1981190227 @default.
• W1981190227 hasRelatedWork W2037434205 @default.
• W1981190227 hasRelatedWork W2076485464 @default.
• W1981190227 hasRelatedWork W2082700441 @default.
• W1981190227 hasRelatedWork W2093244899 @default.
• W1981190227 hasRelatedWork W2117809455 @default.
• W1981190227 hasRelatedWork W2786192066 @default.
• W1981190227 hasRelatedWork W3175861532 @default.
• W1981190227 hasRelatedWork W4318755576 @default.
• W1981190227 hasVolume "20" @default.
• W1981190227 isParatext "false" @default.

• next