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• W1981191573 endingPage "60" @default.
• W1981191573 startingPage "55" @default.
• W1981191573 abstract "We have studied the influence of a wide concentration range of islet amyloid polypeptide (IAPP) on both glucagon and insulin release stimulated by various types of secretagogues. In an islet incubation medium devoid of glucose, the rate of glucagon release being high, we observed a marked suppressive action by low concentrations of IAPP, 10−10 and 10−8 M, on glucagon release. Similarly, glucagon release stimulated by l-arginine, the cholinergic agonist carbachol, or the phosphodiesterase inhibitor isobutylmethyl xanthine (IBMX), an activator of the cyclic AMP system, was inhibited by IAPP in the 10−10 and 10−8 M concentration range. Moreover, basal glucagon release at 7 and 10 mM glucose was suppressed by IAPP. In contrast, IAPP exerted a dual action on insulin release. Hence, low concentrations of IAPP brought about a modest increase of basal insulin secretion at 7 mM glucose and also of insulin release stimulated by carbachol. High concentrations of IAPP, however, inhibited insulin release stimulated by glucose (10 and 16.7 mM), IBMX, carbachol and l-arginine. In conclusion, our data suggest that IAPP has complex effects on islet hormone secretion serving as an inhibitor of glucagon release and having a dual action on insulin secretion exerting mainly a negative feedback on stimulated and a positive feedback on basal insulin release." @default.
• W1981191573 created "2016-06-24" @default.
• W1981191573 creator A5009905641 @default.
• W1981191573 creator A5019063058 @default.
• W1981191573 creator A5075368078 @default.
• W1981191573 creator A5082149530 @default.
• W1981191573 date "2003-03-01" @default.
• W1981191573 modified "2023-10-16" @default.
• W1981191573 title "Islet amyloid polypeptide inhibits glucagon release and exerts a dual action on insulin release from isolated islets" @default.
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• W1981191573 doi "https://doi.org/10.1016/s0167-0115(02)00252-5" @default.
• W1981191573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12609749" @default.
• W1981191573 hasPublicationYear "2003" @default.
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