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- W1981191750 abstract "Members of the TGF-ß superfamily regulate the growth and differentiation of various types of cells. Smads are recently identified proteins that mediate intracellular signaling of the TGF-ß superfamily. Smads are grouped into three classes depending on their structure and functions. R-Smads are phosphorylated by type I serine-threonine kinase receptors for TGF-ß superfamily members. R-Smads then associate with Co-Smads. Smad4 is the only vertebrate Co-Smad identified thus far, and is required for the signaling pathways of different ligands. The heteromeric Smad complex translocates into the nucleus, where it activates target genes. Anti-Smads inhibit signaling by R-Smads and Co-Smads. Smads bind to DNA directly or indirectly via other DNA binding proteins. R-Smads interact with transcriptional coactivators, and have intrinsic transactivation activity. Elucidation of the functions of Smads will provide the framework for research on TGF-ß superfamily signaling." @default.
- W1981191750 created "2016-06-24" @default.
- W1981191750 creator A5051009186 @default.
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- W1981191750 date "1999-01-01" @default.
- W1981191750 modified "2023-10-16" @default.
- W1981191750 title "Signal Transduction of the TGF- Superfamily by Smad Proteins" @default.
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- W1981191750 doi "https://doi.org/10.1093/oxfordjournals.jbchem.a022273" @default.
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