Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981193359> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1981193359 endingPage "3852" @default.
- W1981193359 startingPage "3847" @default.
- W1981193359 abstract "Adenosine, at physiological concentrations, may modulate histamine release from mechanically dispersed human lung mast cells. Addition of adenosine to the dispersed mast cells at times up to 5 min before immunological challenge with anti-human IgE inhibited histamine release. When added after this time adenosine caused a small potentiation of immunological histamine release, maximum potentiation occurring with addition of adenosine 5 min after challenge, coincidental with the end of the rapid phase of histamine release. Both inhibition and potentiation of histamine release were more pronounced with low levels of immunological challenge. Theophylline, 8-phenyltheophylline, dipyridamole and analogues of adenosine were used to determine the site of action of adenosine on mast cell mediator release. Theophylline and 8-phenyltheophylline displaced the concentration-response lines for both inhibition and potentiation of mediator release by adenosine to the right whilst dipyridamole, 1 microM, was without significant effect. This suggests that both effects result from interaction of adenosine with cell surface receptors. This was confirmed by demonstrating that the P-site agonist 2',5'-dideoxyadenosine produced only inhibition of histamine release, an effect which was inhibited by dipyridamole but not by theophylline. The rank potency order of adenosine analogues, NECA much greater than adenosine greater than or equal to L-PIA greater than or equal to D-PIA in both inhibiting and potentiating immunological histamine release suggests that both effects are mediated through activation of cell surface A2-purinoceptors. Since adenosine is released into the circulation of asthmatic subjects following bronchial provocation with antigen, causes bronchoconstriction and has the ability to modulate mast cell histamine release, this nucleoside should be considered as an additional inflammatory mediator of allergic reactions." @default.
- W1981193359 created "2016-06-24" @default.
- W1981193359 creator A5005311406 @default.
- W1981193359 creator A5005327716 @default.
- W1981193359 creator A5089020623 @default.
- W1981193359 date "1984-12-01" @default.
- W1981193359 modified "2023-10-16" @default.
- W1981193359 title "Adenosine inhibits and potentiates IgE-dependent histamine release from human lung mast cells by an A2-purinoceptor mediated mechanism" @default.
- W1981193359 cites W1493241817 @default.
- W1981193359 cites W1963941498 @default.
- W1981193359 cites W1967883006 @default.
- W1981193359 cites W1969142525 @default.
- W1981193359 cites W1974132545 @default.
- W1981193359 cites W1975506706 @default.
- W1981193359 cites W1983380675 @default.
- W1981193359 cites W1996012192 @default.
- W1981193359 cites W2001110103 @default.
- W1981193359 cites W2006756106 @default.
- W1981193359 cites W2064849802 @default.
- W1981193359 cites W2095378950 @default.
- W1981193359 cites W2131767630 @default.
- W1981193359 cites W2556632898 @default.
- W1981193359 cites W4250280224 @default.
- W1981193359 doi "https://doi.org/10.1016/0006-2952(84)90050-9" @default.
- W1981193359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6210089" @default.
- W1981193359 hasPublicationYear "1984" @default.
- W1981193359 type Work @default.
- W1981193359 sameAs 1981193359 @default.
- W1981193359 citedByCount "175" @default.
- W1981193359 countsByYear W19811933592012 @default.
- W1981193359 countsByYear W19811933592013 @default.
- W1981193359 countsByYear W19811933592014 @default.
- W1981193359 countsByYear W19811933592015 @default.
- W1981193359 countsByYear W19811933592016 @default.
- W1981193359 countsByYear W19811933592017 @default.
- W1981193359 countsByYear W19811933592018 @default.
- W1981193359 crossrefType "journal-article" @default.
- W1981193359 hasAuthorship W1981193359A5005311406 @default.
- W1981193359 hasAuthorship W1981193359A5005327716 @default.
- W1981193359 hasAuthorship W1981193359A5089020623 @default.
- W1981193359 hasConcept C1122143 @default.
- W1981193359 hasConcept C126322002 @default.
- W1981193359 hasConcept C134018914 @default.
- W1981193359 hasConcept C170493617 @default.
- W1981193359 hasConcept C172590197 @default.
- W1981193359 hasConcept C185592680 @default.
- W1981193359 hasConcept C203014093 @default.
- W1981193359 hasConcept C2776991684 @default.
- W1981193359 hasConcept C2778095195 @default.
- W1981193359 hasConcept C2778938600 @default.
- W1981193359 hasConcept C2779726688 @default.
- W1981193359 hasConcept C55493867 @default.
- W1981193359 hasConcept C57306754 @default.
- W1981193359 hasConcept C67907053 @default.
- W1981193359 hasConcept C71924100 @default.
- W1981193359 hasConcept C86803240 @default.
- W1981193359 hasConcept C98274493 @default.
- W1981193359 hasConceptScore W1981193359C1122143 @default.
- W1981193359 hasConceptScore W1981193359C126322002 @default.
- W1981193359 hasConceptScore W1981193359C134018914 @default.
- W1981193359 hasConceptScore W1981193359C170493617 @default.
- W1981193359 hasConceptScore W1981193359C172590197 @default.
- W1981193359 hasConceptScore W1981193359C185592680 @default.
- W1981193359 hasConceptScore W1981193359C203014093 @default.
- W1981193359 hasConceptScore W1981193359C2776991684 @default.
- W1981193359 hasConceptScore W1981193359C2778095195 @default.
- W1981193359 hasConceptScore W1981193359C2778938600 @default.
- W1981193359 hasConceptScore W1981193359C2779726688 @default.
- W1981193359 hasConceptScore W1981193359C55493867 @default.
- W1981193359 hasConceptScore W1981193359C57306754 @default.
- W1981193359 hasConceptScore W1981193359C67907053 @default.
- W1981193359 hasConceptScore W1981193359C71924100 @default.
- W1981193359 hasConceptScore W1981193359C86803240 @default.
- W1981193359 hasConceptScore W1981193359C98274493 @default.
- W1981193359 hasIssue "23" @default.
- W1981193359 hasLocation W19811933591 @default.
- W1981193359 hasLocation W19811933592 @default.
- W1981193359 hasOpenAccess W1981193359 @default.
- W1981193359 hasPrimaryLocation W19811933591 @default.
- W1981193359 hasRelatedWork W118860913 @default.
- W1981193359 hasRelatedWork W1973996182 @default.
- W1981193359 hasRelatedWork W1975359674 @default.
- W1981193359 hasRelatedWork W1981193359 @default.
- W1981193359 hasRelatedWork W2061061336 @default.
- W1981193359 hasRelatedWork W2095209822 @default.
- W1981193359 hasRelatedWork W2104698425 @default.
- W1981193359 hasRelatedWork W2111623241 @default.
- W1981193359 hasRelatedWork W2803301966 @default.
- W1981193359 hasRelatedWork W331448635 @default.
- W1981193359 hasVolume "33" @default.
- W1981193359 isParatext "false" @default.
- W1981193359 isRetracted "false" @default.
- W1981193359 magId "1981193359" @default.
- W1981193359 workType "article" @default.