FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981193744> ?p ?o ?g. }

• W1981193744 endingPage "R631" @default.
• W1981193744 startingPage "R623" @default.
• W1981193744 abstract "Circulating amylin inhibits food intake via activation of the area postrema (AP). The aim of this study was to identify the neurochemical phenotype of the neurons mediating amylin's hypophagic action by immunohistochemical and feeding studies in rats. Expression of c-Fos protein was used as a marker for neuronal activation and dopamine-β-hydroxylase (DBH), the enzyme-catalyzing noradrenaline synthesis, as a marker for noradrenergic neurons. We found that ∼50% of amylin-activated AP neurons are noradrenergic. To clarify the functional role of these neurons in amylin's effect on eating, noradrenaline-containing neurons in the AP were lesioned using a saporin conjugated to an antibody against DBH. Amylin (5 or 20 μg/kg sc)-induced anorexia was observed in sham-lesioned rats with both amylin doses. Rats with a lesion of > 50% of the noradrenaline neurons were unresponsive to the low dose of amylin (5 μg/kg) and only displayed a reduction in food intake 60 min after injection of the high amylin dose (20 μg/kg). In a terminal experiment, the same rats received amylin (20 μg/kg) or saline. The AP and nucleus of the solitary tract (NTS) were stained for DBH to assess noradrenaline lesion success and for c-Fos expression to evaluate amylin-induced neuronal activation. In contrast to sham-lesioned animals, noradrenaline-lesioned rats did not show a significant increase in amylin-induced c-Fos expression in the AP and NTS. We conclude that the noradrenergic neurons in the AP mediate at least part of amylin's hypophagic effect." @default.
• W1981193744 created "2016-06-24" @default.
• W1981193744 creator A5014137251 @default.
• W1981193744 creator A5040977375 @default.
• W1981193744 creator A5045376870 @default.
• W1981193744 creator A5051563501 @default.
• W1981193744 creator A5052505787 @default.
• W1981193744 creator A5060577478 @default.
• W1981193744 creator A5077735265 @default.
• W1981193744 creator A5086331303 @default.
• W1981193744 date "2010-08-01" @default.
• W1981193744 modified "2023-10-10" @default.
• W1981193744 title "Noradrenergic neurons of the area postrema mediate amylin's hypophagic action" @default.
• W1981193744 cites W1515729057 @default.
• W1981193744 cites W1595123071 @default.
• W1981193744 cites W1968761153 @default.
• W1981193744 cites W1977218349 @default.
• W1981193744 cites W1979682661 @default.
• W1981193744 cites W1980380325 @default.
• W1981193744 cites W1982661346 @default.
• W1981193744 cites W1988002552 @default.
• W1981193744 cites W2004323757 @default.
• W1981193744 cites W2005677989 @default.
• W1981193744 cites W2009538435 @default.
• W1981193744 cites W2018206955 @default.
• W1981193744 cites W2018895555 @default.
• W1981193744 cites W2023605292 @default.
• W1981193744 cites W2023851192 @default.
• W1981193744 cites W2024958149 @default.
• W1981193744 cites W2033334867 @default.
• W1981193744 cites W2036602783 @default.
• W1981193744 cites W2043810892 @default.
• W1981193744 cites W2049795844 @default.
• W1981193744 cites W2053794928 @default.
• W1981193744 cites W2054705005 @default.
• W1981193744 cites W2054815978 @default.
• W1981193744 cites W2058343593 @default.
• W1981193744 cites W2070594264 @default.
• W1981193744 cites W2070772419 @default.
• W1981193744 cites W2074668557 @default.
• W1981193744 cites W2075691591 @default.
• W1981193744 cites W2076540171 @default.
• W1981193744 cites W2083066144 @default.
• W1981193744 cites W2089157277 @default.
• W1981193744 cites W2090235818 @default.
• W1981193744 cites W2091231206 @default.
• W1981193744 cites W2097975060 @default.
• W1981193744 cites W2101301575 @default.
• W1981193744 cites W2102695417 @default.
• W1981193744 cites W2106924629 @default.
• W1981193744 cites W2107135308 @default.
• W1981193744 cites W2115756463 @default.
• W1981193744 cites W2133851735 @default.
• W1981193744 cites W2144184072 @default.
• W1981193744 cites W2186341992 @default.
• W1981193744 cites W2315517171 @default.
• W1981193744 cites W2317720845 @default.
• W1981193744 doi "https://doi.org/10.1152/ajpregu.00791.2009" @default.
• W1981193744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20554938" @default.
• W1981193744 hasPublicationYear "2010" @default.
• W1981193744 type Work @default.
• W1981193744 sameAs 1981193744 @default.
• W1981193744 citedByCount "65" @default.
• W1981193744 countsByYear W19811937442012 @default.
• W1981193744 countsByYear W19811937442013 @default.
• W1981193744 countsByYear W19811937442014 @default.
• W1981193744 countsByYear W19811937442015 @default.
• W1981193744 countsByYear W19811937442016 @default.
• W1981193744 countsByYear W19811937442017 @default.
• W1981193744 countsByYear W19811937442018 @default.
• W1981193744 countsByYear W19811937442019 @default.
• W1981193744 countsByYear W19811937442020 @default.
• W1981193744 countsByYear W19811937442021 @default.
• W1981193744 countsByYear W19811937442022 @default.
• W1981193744 countsByYear W19811937442023 @default.
• W1981193744 crossrefType "journal-article" @default.
• W1981193744 hasAuthorship W1981193744A5014137251 @default.
• W1981193744 hasAuthorship W1981193744A5040977375 @default.
• W1981193744 hasAuthorship W1981193744A5045376870 @default.
• W1981193744 hasAuthorship W1981193744A5051563501 @default.
• W1981193744 hasAuthorship W1981193744A5052505787 @default.
• W1981193744 hasAuthorship W1981193744A5060577478 @default.
• W1981193744 hasAuthorship W1981193744A5077735265 @default.
• W1981193744 hasAuthorship W1981193744A5086331303 @default.
• W1981193744 hasConcept C118303440 @default.
• W1981193744 hasConcept C126322002 @default.
• W1981193744 hasConcept C134018914 @default.
• W1981193744 hasConcept C165220095 @default.
• W1981193744 hasConcept C170493617 @default.
• W1981193744 hasConcept C185592680 @default.
• W1981193744 hasConcept C25876315 @default.
• W1981193744 hasConcept C2776459250 @default.
• W1981193744 hasConcept C2779306644 @default.
• W1981193744 hasConcept C2780705028 @default.
• W1981193744 hasConcept C2780838160 @default.
• W1981193744 hasConcept C513476851 @default.
• W1981193744 hasConcept C529278444 @default.
• W1981193744 hasConcept C71924100 @default.

• next