Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981199232> ?p ?o ?g. }
- W1981199232 endingPage "1265" @default.
- W1981199232 startingPage "1259" @default.
- W1981199232 abstract "CXC chemokine receptor 4 (CXCR4) is a G protein-coupled receptor implicated in cell entry of T-cell line-tropic HIV-1 strains. CXCR4 and its ligand stromal cell derived factor-1 (SDF-1)/CXCL12 play pivotal parts in many physiological processes and pathogenetic conditions (e.g., immune cell-homing and cancer metastasis). We previously developed the potent CXCR4 antagonist T140 from structure-activity relationship studies of the antimicrobial peptide polyphemusin II. T140 and its derivatives have been exploited in biological and biomedical studies for the SDF-1/CXCR4 axis. We investigated receptor localization upon ligand stimulation using fluorescent SDF-1 and T140 derivatives as well as a specific labeling technique for cellular-membrane CXCR4. Fluorescent T140 derivatives induced translocation of CXCR4 into the perinuclear region as observed by treatment with fluorescent SDF-1. T140 derivative-mediated internalization of CXCR4 was also monitored by the coiled-coil tag-probe system. These findings demonstrated that the CXCR4 antagonistic activity and anti-HIV activity of T140 derivatives were derived (at least in part) from antagonist-mediated receptor internalization." @default.
- W1981199232 created "2016-06-24" @default.
- W1981199232 creator A5011973217 @default.
- W1981199232 creator A5012808950 @default.
- W1981199232 creator A5013135912 @default.
- W1981199232 creator A5020366722 @default.
- W1981199232 creator A5033128839 @default.
- W1981199232 creator A5039560593 @default.
- W1981199232 creator A5065647772 @default.
- W1981199232 creator A5079668567 @default.
- W1981199232 creator A5082481492 @default.
- W1981199232 creator A5083134524 @default.
- W1981199232 creator A5083344330 @default.
- W1981199232 date "2012-05-09" @default.
- W1981199232 modified "2023-09-25" @default.
- W1981199232 title "Paradoxical Downregulation of CXC Chemokine Receptor 4 Induced by Polyphemusin II-Derived Antagonists" @default.
- W1981199232 cites W1501974099 @default.
- W1981199232 cites W1567845952 @default.
- W1981199232 cites W1872945166 @default.
- W1981199232 cites W1963984954 @default.
- W1981199232 cites W1964083898 @default.
- W1981199232 cites W1964204604 @default.
- W1981199232 cites W1976223354 @default.
- W1981199232 cites W1988087328 @default.
- W1981199232 cites W1989035987 @default.
- W1981199232 cites W1994168866 @default.
- W1981199232 cites W2001147456 @default.
- W1981199232 cites W2019215631 @default.
- W1981199232 cites W2027781307 @default.
- W1981199232 cites W2028035233 @default.
- W1981199232 cites W2034711213 @default.
- W1981199232 cites W2046844598 @default.
- W1981199232 cites W2049412263 @default.
- W1981199232 cites W2056918364 @default.
- W1981199232 cites W2063496130 @default.
- W1981199232 cites W2064500527 @default.
- W1981199232 cites W2067115133 @default.
- W1981199232 cites W2069156204 @default.
- W1981199232 cites W2077886045 @default.
- W1981199232 cites W2078373009 @default.
- W1981199232 cites W2078389180 @default.
- W1981199232 cites W2092851520 @default.
- W1981199232 cites W2094843483 @default.
- W1981199232 cites W2117394497 @default.
- W1981199232 cites W2128845370 @default.
- W1981199232 cites W2134969288 @default.
- W1981199232 cites W2138534902 @default.
- W1981199232 cites W2142899629 @default.
- W1981199232 cites W2144172655 @default.
- W1981199232 cites W2144568772 @default.
- W1981199232 cites W2146192265 @default.
- W1981199232 cites W2149689090 @default.
- W1981199232 cites W2152853006 @default.
- W1981199232 cites W2154229564 @default.
- W1981199232 cites W2158294445 @default.
- W1981199232 cites W2169931649 @default.
- W1981199232 cites W4211264883 @default.
- W1981199232 cites W4254841581 @default.
- W1981199232 doi "https://doi.org/10.1021/bc300084h" @default.
- W1981199232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22486464" @default.
- W1981199232 hasPublicationYear "2012" @default.
- W1981199232 type Work @default.
- W1981199232 sameAs 1981199232 @default.
- W1981199232 citedByCount "7" @default.
- W1981199232 countsByYear W19811992322013 @default.
- W1981199232 countsByYear W19811992322015 @default.
- W1981199232 countsByYear W19811992322017 @default.
- W1981199232 countsByYear W19811992322019 @default.
- W1981199232 countsByYear W19811992322020 @default.
- W1981199232 crossrefType "journal-article" @default.
- W1981199232 hasAuthorship W1981199232A5011973217 @default.
- W1981199232 hasAuthorship W1981199232A5012808950 @default.
- W1981199232 hasAuthorship W1981199232A5013135912 @default.
- W1981199232 hasAuthorship W1981199232A5020366722 @default.
- W1981199232 hasAuthorship W1981199232A5033128839 @default.
- W1981199232 hasAuthorship W1981199232A5039560593 @default.
- W1981199232 hasAuthorship W1981199232A5065647772 @default.
- W1981199232 hasAuthorship W1981199232A5079668567 @default.
- W1981199232 hasAuthorship W1981199232A5082481492 @default.
- W1981199232 hasAuthorship W1981199232A5083134524 @default.
- W1981199232 hasAuthorship W1981199232A5083344330 @default.
- W1981199232 hasConcept C12554922 @default.
- W1981199232 hasConcept C12823836 @default.
- W1981199232 hasConcept C129470790 @default.
- W1981199232 hasConcept C13373296 @default.
- W1981199232 hasConcept C135285700 @default.
- W1981199232 hasConcept C139770010 @default.
- W1981199232 hasConcept C151872237 @default.
- W1981199232 hasConcept C16930146 @default.
- W1981199232 hasConcept C170493617 @default.
- W1981199232 hasConcept C185592680 @default.
- W1981199232 hasConcept C18903297 @default.
- W1981199232 hasConcept C2780492938 @default.
- W1981199232 hasConcept C45240729 @default.
- W1981199232 hasConcept C502942594 @default.
- W1981199232 hasConcept C55493867 @default.
- W1981199232 hasConcept C84913492 @default.
- W1981199232 hasConcept C86803240 @default.