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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981199451> ?p ?o ?g. }

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• W1981199451 abstract "Oligosaccharide moieties of cell-surface glycoproteins are thought to be involved in recognition events during cancer metastasis and invasion. Swainsonine, an inhibitor of the Golgi alpha-mannosidase II, has been shown to block pulmonary colonization by tumor cells and stimulate components of the immune system. Swainsonine also abrogates much of the toxicity of chemotherapeutic agents and stimulates bone marrow hematopoietic progenitor cells, suggesting additional therapeutic applications. We are currently characterizing the ability of swainsonine to modify cell growth in human and murine bone marrow progenitor cells. Furthermore, we are examining crucial steps in metastasis that depend upon cell surface molecules that play a role in cell-matrix interactions. Our work shows that tumor cell adhesion to collagen IV in vitro is rapidly stimulated by cis-polyunsaturated fatty acids and is dependent on protein kinase C activity. We are investigating the hypothesis that integrins are critical components of this adhesion and are examining potential signal transduction pathways that lead to the modulation of cell adhesion." @default.
• W1981199451 created "2016-06-24" @default.
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• W1981199451 date "1998-09-01" @default.
• W1981199451 modified "2023-10-07" @default.
• W1981199451 title "The Role of Protein Glycosylation Inhibitors in the Prevention of Metastasis and Therapy of Cancer" @default.
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• W1981199451 doi "https://doi.org/10.1046/j.1525-1500.1998.00054.x" @default.
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