FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981224477> ?p ?o ?g. }

• W1981224477 endingPage "191" @default.
• W1981224477 startingPage "176" @default.
• W1981224477 abstract "There is substantial evidence of mitochondrial defects in neurodegenerative disorders such as Alzheimer's and Parkinson's diseases (AD and PD). We have probed the molecular implications of mitochondrial dysfunction in these diseases by transferring mitochondria from platelets obtained from disease and control donors into mitochondrial DNA-depleted recipient neuron-based cells (rho 0 cells). This process creates cytoplasmic hybrid (cybrid) cells where the mitochondrial DNA (mtDNA) from the donor is expressed in the nuclear and cellular background of the host rho 0 cell. Differences in phenotype between disease and control groups can thus be attributed to the exogenous mitochondria and mtDNA. Key methodological issues relating to this approach were addressed by demonstrating that recipient rho 0 cells have < 1 mtDNA copy/cell, and that exclusive repopulation with donor mtDNA occurs in cybrid cells. Further, we describe that sampling of heterogeneous cell populations is a valid approach for cybrid analysis. Our studies show that the focal respiratory chain defects reported in platelets of AD and PD cybrids can be recapitulated in AD and PD cybrids. In addition, both AD and PD cybrids display increased oxidative stress and perturbations in calcium homeostasis. These data suggest that the transfer of a mtDNA defect from disease donor platelets is the likely cause of the cybrid biochemical phenotype, and highlight the potential value of these cell lines as cellular disease models." @default.
• W1981224477 created "2016-06-24" @default.
• W1981224477 creator A5001023467 @default.
• W1981224477 creator A5018227983 @default.
• W1981224477 creator A5024859835 @default.
• W1981224477 creator A5050249978 @default.
• W1981224477 creator A5078171411 @default.
• W1981224477 creator A5080701650 @default.
• W1981224477 date "1999-11-01" @default.
• W1981224477 modified "2023-09-23" @default.
• W1981224477 title "Use of Cytoplasmic Hybrid Cell Lines for Elucidating the Role of Mitochondrial Dysfunction in Alzheimer's Disease and Parkinson's Disease" @default.
• W1981224477 cites W1480429336 @default.
• W1981224477 cites W1532873251 @default.
• W1981224477 cites W1966955565 @default.
• W1981224477 cites W1967045147 @default.
• W1981224477 cites W1969257616 @default.
• W1981224477 cites W1969800514 @default.
• W1981224477 cites W1972542632 @default.
• W1981224477 cites W1974779272 @default.
• W1981224477 cites W1977280291 @default.
• W1981224477 cites W1980680603 @default.
• W1981224477 cites W1983178060 @default.
• W1981224477 cites W1985667235 @default.
• W1981224477 cites W1987301978 @default.
• W1981224477 cites W1988731658 @default.
• W1981224477 cites W1992441672 @default.
• W1981224477 cites W1993437043 @default.
• W1981224477 cites W2001309934 @default.
• W1981224477 cites W2005045122 @default.
• W1981224477 cites W2005718633 @default.
• W1981224477 cites W2016787732 @default.
• W1981224477 cites W2020138346 @default.
• W1981224477 cites W2022164794 @default.
• W1981224477 cites W2024046487 @default.
• W1981224477 cites W2025931289 @default.
• W1981224477 cites W2026674234 @default.
• W1981224477 cites W2029750351 @default.
• W1981224477 cites W2032350023 @default.
• W1981224477 cites W2039510514 @default.
• W1981224477 cites W2040892857 @default.
• W1981224477 cites W2041155216 @default.
• W1981224477 cites W2045872066 @default.
• W1981224477 cites W2047819781 @default.
• W1981224477 cites W205203631 @default.
• W1981224477 cites W2059543204 @default.
• W1981224477 cites W2061500679 @default.
• W1981224477 cites W2062673250 @default.
• W1981224477 cites W2066994081 @default.
• W1981224477 cites W2075527716 @default.
• W1981224477 cites W2077260129 @default.
• W1981224477 cites W2077649619 @default.
• W1981224477 cites W2082185635 @default.
• W1981224477 cites W2092146469 @default.
• W1981224477 cites W2104409043 @default.
• W1981224477 cites W2109656063 @default.
• W1981224477 cites W2110288755 @default.
• W1981224477 cites W2112602336 @default.
• W1981224477 cites W2112777355 @default.
• W1981224477 cites W2133396109 @default.
• W1981224477 cites W2136372119 @default.
• W1981224477 cites W2146502895 @default.
• W1981224477 cites W2150656456 @default.
• W1981224477 cites W2153582938 @default.
• W1981224477 cites W2154744393 @default.
• W1981224477 cites W2155395884 @default.
• W1981224477 cites W2168493882 @default.
• W1981224477 cites W3149792679 @default.
• W1981224477 cites W4254119740 @default.
• W1981224477 cites W4320578147 @default.
• W1981224477 cites W4362172418 @default.
• W1981224477 doi "https://doi.org/10.1111/j.1749-6632.1999.tb07825.x" @default.
• W1981224477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10672237" @default.
• W1981224477 hasPublicationYear "1999" @default.
• W1981224477 type Work @default.
• W1981224477 sameAs 1981224477 @default.
• W1981224477 citedByCount "86" @default.
• W1981224477 countsByYear W19812244772012 @default.
• W1981224477 countsByYear W19812244772013 @default.
• W1981224477 countsByYear W19812244772014 @default.
• W1981224477 countsByYear W19812244772015 @default.
• W1981224477 countsByYear W19812244772016 @default.
• W1981224477 countsByYear W19812244772017 @default.
• W1981224477 countsByYear W19812244772018 @default.
• W1981224477 countsByYear W19812244772019 @default.
• W1981224477 countsByYear W19812244772020 @default.
• W1981224477 countsByYear W19812244772021 @default.
• W1981224477 countsByYear W19812244772022 @default.
• W1981224477 countsByYear W19812244772023 @default.
• W1981224477 crossrefType "journal-article" @default.
• W1981224477 hasAuthorship W1981224477A5001023467 @default.
• W1981224477 hasAuthorship W1981224477A5018227983 @default.
• W1981224477 hasAuthorship W1981224477A5024859835 @default.
• W1981224477 hasAuthorship W1981224477A5050249978 @default.
• W1981224477 hasAuthorship W1981224477A5078171411 @default.
• W1981224477 hasAuthorship W1981224477A5080701650 @default.
• W1981224477 hasConcept C104317684 @default.
• W1981224477 hasConcept C127716648 @default.
• W1981224477 hasConcept C1491633281 @default.

• next