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- W1981230076 abstract "Current strategies for posttransplant monitoring of kidney transplants consist of measuring serial serum creatinine levels, clinical follow-up, and in some programs, protocol biopsies. These strategies may be insufficient to predict acute rejection in kidney transplants, which remains the major factor affecting long-term transplant outcomes. Immune monitoring may conceptually be divided into strategies for detecting humoral rejection (eg, donor-specific antibody) or cellular rejection. Cellular rejection markers may be separated further into those related to cytotoxic T lymphocytes (granzyme A/B, perforin, Fas ligand, and serpin B9), regulatory T cells (FOXP3), and CD4 T cells (the chemokines CXCL9, CXCL10, CXCL11, CCL2, and fractalkine, as well as TIM-3). Finally, transcriptomic changes and renal tubular injury markers also may be useful for detecting early inflammatory changes post–kidney transplant. Ultimately, novel strategies for monitoring the immune status of the kidney transplant may lead to early therapeutic intervention and improved kidney transplant outcomes. Current strategies for posttransplant monitoring of kidney transplants consist of measuring serial serum creatinine levels, clinical follow-up, and in some programs, protocol biopsies. These strategies may be insufficient to predict acute rejection in kidney transplants, which remains the major factor affecting long-term transplant outcomes. Immune monitoring may conceptually be divided into strategies for detecting humoral rejection (eg, donor-specific antibody) or cellular rejection. Cellular rejection markers may be separated further into those related to cytotoxic T lymphocytes (granzyme A/B, perforin, Fas ligand, and serpin B9), regulatory T cells (FOXP3), and CD4 T cells (the chemokines CXCL9, CXCL10, CXCL11, CCL2, and fractalkine, as well as TIM-3). Finally, transcriptomic changes and renal tubular injury markers also may be useful for detecting early inflammatory changes post–kidney transplant. Ultimately, novel strategies for monitoring the immune status of the kidney transplant may lead to early therapeutic intervention and improved kidney transplant outcomes." @default.
- W1981230076 created "2016-06-24" @default.
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- W1981230076 date "2012-10-01" @default.
- W1981230076 modified "2023-09-27" @default.
- W1981230076 title "Immune Monitoring of Kidney Allografts" @default.
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- W1981230076 doi "https://doi.org/10.1053/j.ajkd.2012.01.028" @default.
- W1981230076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22542291" @default.
- W1981230076 hasPublicationYear "2012" @default.
- W1981230076 type Work @default.