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- W1981234524 endingPage "19" @default.
- W1981234524 startingPage "9" @default.
- W1981234524 abstract "Hypothermia is the most potent neuroprotective therapy available. Clinical use of hypothermia is limited by technology and homeostatic mechanisms that maintain core body temperature. Recent advances in intravascular cooling catheters and successful trials of hypothermia for cardiac arrest revivified interest in hypothermia for stroke, resulting in Phase 1 clinical trials and plans for further development. Given the recent spate of neuroprotective therapy failures, we sought to clarify whether clinical trials of therapeutic hypothermia should be mounted in stroke patients. We reviewed the preclinical and early clinical trials of hypothermia for a variety of indications, the putative mechanisms for neuroprotection with hypothermia, and offer several hypotheses that remain to be tested in clinical trials. Therapeutic hypothermia is promising, but further Phase 1 and Phase 2 development efforts are needed to ensure that cooling of stroke patients is safe, before definitive efficacy trials." @default.
- W1981234524 created "2016-06-24" @default.
- W1981234524 creator A5011373172 @default.
- W1981234524 creator A5016571028 @default.
- W1981234524 creator A5041277234 @default.
- W1981234524 creator A5086474167 @default.
- W1981234524 date "2006-02-01" @default.
- W1981234524 modified "2023-10-15" @default.
- W1981234524 title "Therapeutic Hypothermia for Acute Stroke" @default.
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