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- W1981255838 abstract "Heat shock proteins (hsp) have attracted considerable attention from immunologists over the last 20 years, and their interest has evolved in three distinct phases. Initially hsp were investigated primarily as antigens, particularly when it was found that they were rather common targets of both the humoral and T cell-mediated responses to intracellular pathogens like mycobacteria. Their recognition by T cells in models of autoimmune disease, particularly arthritis and diabetes, gave rise to much speculation that immune responses initially directed against hsp from pathogens might cross-react with self antigens including hsp themselves [1,2]. Since hsp are often up-regulated at sites of inflammation this would provide opportunities for persistent stimulation of cross-reactive hsp-specific T cells [3]. Such speculation continues, although more recent evidence points to anti-inflammatory properties of T cells which recognize self hsp rather than their ability to induce autoimmune disease [4]." @default.
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- W1981255838 date "2002-01-01" @default.
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- W1981255838 title "Heat shock proteins and innate immunity" @default.
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- W1981255838 doi "https://doi.org/10.1046/j.1365-2249.2002.01759.x" @default.
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