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• W1981266280 abstract "The poly[La–(Glc–Leu)] copolymer was applied in the present investigation as polymeric carrier to fabricate naltrexone (NTX)-loaded poly[La–(Glc–Leu)] microspheres in the single emulsion solvent evaporation technique for the long-term treatment of alcohol dependence. Newly synthesized poly[La–(Glc–Leu)] copolymer exhibited diminished crystallanity, good biocompatibility and favorable biodegradability to be explored for drug delivery application. Scanning Electron Microscopy study revealed smooth and spherical-shaped NTX-loaded polymeric microspheres with a mean size of 10–90 µm. Influence of various decisive formulation variables such as amount of polymer, stabilizer concentration, homogenization speed, homogenization time, drug loading and organic-to-aqueous phase ratio on particle size, and entrapment efficiency was studied. Differential scanning calorimeter and X-ray diffractometry study confirmed the drug entrapment within polymer matrix into the microsphere environment. In vitro drug release showed the sustained drug release of formulation for the period of 28 d giving biphasic release pattern. Histological examination of NTX-loaded poly[La–(Glc–Leu)] microspheres injected intramuscularly into the thigh muscle of Wistar rats showed minimal inflammatory reaction, demonstrating that NTX-loaded microspheres were biocompatible. Insignificant increase in the serum creatine phosphokinase level (p < 0.05) as compared with the normal value revealed good muscle compatibility of the poly[La–(Glc–Leu)] microsphere system. Biocompatible nature and sustained drug-release action of poly[La–(Glc–Leu)] microspheres may have potential application in depot therapy." @default.
• W1981266280 created "2016-06-24" @default.
• W1981266280 creator A5058679460 @default.
• W1981266280 creator A5065374337 @default.
• W1981266280 date "2013-04-16" @default.
• W1981266280 modified "2023-09-23" @default.
• W1981266280 title "Naltrexone-loaded poly[La–(Glc–Leu)] polymeric microspheres for the treatment of alcohol dependence:<i>in vitro</i>characterization and<i>in vivo</i>biocompatibility assessment" @default.
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• W1981266280 doi "https://doi.org/10.3109/10837450.2013.784334" @default.
• W1981266280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23590187" @default.
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