FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981305733> ?p ?o ?g. }

• W1981305733 endingPage "282" @default.
• W1981305733 startingPage "275" @default.
• W1981305733 abstract "Selective estrogen receptor (ER) agonists can indicate which receptor subtypes are implicated in neuroprotection. This study investigated the contribution of ERbeta, using the selective agonist diarylpropiolnitrile (DPN), in a rat model of stroke. Lister Hooded rats were ovariectomized and implanted with mini-pumps containing either DPN (8 mg kg(-1) day(-1)) (n=7) or vehicle (n=5). Sensorimotor function was assessed using a neurological score and the spontaneous forelimb use asymmetry (cylinder) test. One week later the animals received a middle cerebral artery occlusion (MCAO), and T(2)-weighted MRI at 48 h post-MCAO quantified ischemic damage. Functional recovery was tested for 7 days post-MCAO and brains processed for histological verification of infarct size. The MRI images revealed no significant differences in hemispheric lesion volumes between vehicle- and DPN-treated groups (35.6+/-3.5% and 30.8+/-1.7%, respectively [mean+/-SEM]; Student's unpaired t-test df=10, t=-1.357, p=0.453); this was confirmed histologically at 7 days. MCAO induced significant decline in neurological score performance (from 22 to 11 at 2 h post-MCAO) in the vehicle-treated animals, which was not significantly influenced by DPN. MCAO also induced significant changes in forelimb use in the cylinder test (10% reduction in contralateral, 20% reduction in both, and 30% increase in ipsilateral forelimb use) but this response was not significantly different between groups [F(1,1)=2.929, p=0.118, repeated-measures ANOVA]. In conclusion, pretreatment with the ERbeta agonist DPN did not influence infarct size or sensorimotor function in rats exposed to MCAO." @default.
• W1981305733 created "2016-06-24" @default.
• W1981305733 creator A5000724327 @default.
• W1981305733 creator A5031862740 @default.
• W1981305733 creator A5033743694 @default.
• W1981305733 creator A5041968296 @default.
• W1981305733 date "2007-12-01" @default.
• W1981305733 modified "2023-09-27" @default.
• W1981305733 title "Estrogen receptor beta agonist diarylpropiolnitrile (DPN) does not mediate neuroprotection in a rat model of permanent focal ischemia" @default.
• W1981305733 cites W1956013732 @default.
• W1981305733 cites W1973772110 @default.
• W1981305733 cites W1978867503 @default.
• W1981305733 cites W1980147601 @default.
• W1981305733 cites W1983538594 @default.
• W1981305733 cites W1988503833 @default.
• W1981305733 cites W1990646008 @default.
• W1981305733 cites W1995860303 @default.
• W1981305733 cites W2000279141 @default.
• W1981305733 cites W2013448781 @default.
• W1981305733 cites W2020677897 @default.
• W1981305733 cites W2024017898 @default.
• W1981305733 cites W2025585440 @default.
• W1981305733 cites W2026255271 @default.
• W1981305733 cites W2028504212 @default.
• W1981305733 cites W2037519066 @default.
• W1981305733 cites W2038636807 @default.
• W1981305733 cites W2039725741 @default.
• W1981305733 cites W2041440858 @default.
• W1981305733 cites W2045835005 @default.
• W1981305733 cites W2066710181 @default.
• W1981305733 cites W2073353512 @default.
• W1981305733 cites W2073672013 @default.
• W1981305733 cites W2082006898 @default.
• W1981305733 cites W2085641843 @default.
• W1981305733 cites W2087632836 @default.
• W1981305733 cites W2092411075 @default.
• W1981305733 cites W2098093165 @default.
• W1981305733 cites W2099754898 @default.
• W1981305733 cites W2115190197 @default.
• W1981305733 cites W2125063109 @default.
• W1981305733 cites W2128945352 @default.
• W1981305733 cites W2145865543 @default.
• W1981305733 cites W2156965301 @default.
• W1981305733 cites W2158477450 @default.
• W1981305733 cites W2162934389 @default.
• W1981305733 doi "https://doi.org/10.1016/j.brainres.2007.09.009" @default.
• W1981305733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17942083" @default.
• W1981305733 hasPublicationYear "2007" @default.
• W1981305733 type Work @default.
• W1981305733 sameAs 1981305733 @default.
• W1981305733 citedByCount "30" @default.
• W1981305733 countsByYear W19813057332012 @default.
• W1981305733 countsByYear W19813057332013 @default.
• W1981305733 countsByYear W19813057332014 @default.
• W1981305733 countsByYear W19813057332016 @default.
• W1981305733 countsByYear W19813057332017 @default.
• W1981305733 countsByYear W19813057332018 @default.
• W1981305733 countsByYear W19813057332019 @default.
• W1981305733 countsByYear W19813057332020 @default.
• W1981305733 crossrefType "journal-article" @default.
• W1981305733 hasAuthorship W1981305733A5000724327 @default.
• W1981305733 hasAuthorship W1981305733A5031862740 @default.
• W1981305733 hasAuthorship W1981305733A5033743694 @default.
• W1981305733 hasAuthorship W1981305733A5041968296 @default.
• W1981305733 hasConcept C105702510 @default.
• W1981305733 hasConcept C121608353 @default.
• W1981305733 hasConcept C126322002 @default.
• W1981305733 hasConcept C127413603 @default.
• W1981305733 hasConcept C134018914 @default.
• W1981305733 hasConcept C170493617 @default.
• W1981305733 hasConcept C25498285 @default.
• W1981305733 hasConcept C2777164284 @default.
• W1981305733 hasConcept C2778646069 @default.
• W1981305733 hasConcept C2778938600 @default.
• W1981305733 hasConcept C2780645631 @default.
• W1981305733 hasConcept C42219234 @default.
• W1981305733 hasConcept C530470458 @default.
• W1981305733 hasConcept C541997718 @default.
• W1981305733 hasConcept C71924100 @default.
• W1981305733 hasConcept C78519656 @default.
• W1981305733 hasConcept C8264082 @default.
• W1981305733 hasConcept C84606932 @default.
• W1981305733 hasConcept C99476002 @default.
• W1981305733 hasConceptScore W1981305733C105702510 @default.
• W1981305733 hasConceptScore W1981305733C121608353 @default.
• W1981305733 hasConceptScore W1981305733C126322002 @default.
• W1981305733 hasConceptScore W1981305733C127413603 @default.
• W1981305733 hasConceptScore W1981305733C134018914 @default.
• W1981305733 hasConceptScore W1981305733C170493617 @default.
• W1981305733 hasConceptScore W1981305733C25498285 @default.
• W1981305733 hasConceptScore W1981305733C2777164284 @default.
• W1981305733 hasConceptScore W1981305733C2778646069 @default.
• W1981305733 hasConceptScore W1981305733C2778938600 @default.
• W1981305733 hasConceptScore W1981305733C2780645631 @default.
• W1981305733 hasConceptScore W1981305733C42219234 @default.
• W1981305733 hasConceptScore W1981305733C530470458 @default.
• W1981305733 hasConceptScore W1981305733C541997718 @default.
• W1981305733 hasConceptScore W1981305733C71924100 @default.

• next