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- W1981306589 abstract "Impulsivity has often been assumed to be a unitary construct. However dissociable forms of impulsive behaviour may exist, each with distinct neurochemical underpinnings. To test this hypothesis, behavioural effects of three partially selective serotonergic (5-HT) ligands, ketanserin (5-HT2 A, C receptor antagonist), SER-082 (5-HT2 C, B receptor antagonist) and SB-270146-A (5-HT6 receptor antagonist) were compared in two tests of impulsivity. The five-choice serial reaction time task (5-csrtt) and a delayed reward task were chosen as they measure theoretically different types of impulsivity, behavioural inhibition versus choice preference for a delayed reward. Dissociation was seen between the effects of ketanserin, which decreased impulsivity in the 5-csrtt, but had no effect on the delayed reward task, and SER-082, which had no effect on the 5-csrtt, but decreased impulsive responding in the delayed reward task. SB-270146-A had no effect in either paradigm. The results suggest that the 5-csrtt and the delayed reward task do in fact measure different types of impulsive behaviour, which are at least partially neurochemically distinct." @default.
- W1981306589 created "2016-06-24" @default.
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- W1981306589 date "2005-10-04" @default.
- W1981306589 modified "2023-10-16" @default.
- W1981306589 title "A comparison of multiple 5-HT receptors in two tasks measuring impulsivity" @default.
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- W1981306589 doi "https://doi.org/10.1177/0269881105056639" @default.
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