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- W1981308974 abstract "1.1. Isolated hemibladders of the fresh-water turtle, Pseudemys scripta, were bathed on both surfaces by an oxygenated Na+-free choline-Ringer solution (17 mM HCO3−-Krebs buffer) and were maintained in a short-circuited state. Forward (mucosal to serosal) clearance of 22Na+ was measured. Clearance (μl/h) was defined as the forward flux (nmoles/h) per unit of mucosal Na+ concentration (mM). When serosal [Na+] < 0.5 mM and mucosal [Na+] < 0.1 mM, clearance progressively and spontaneously decreased at an average rate of 29%/h.2.2. During the period of progressive decline, nonradioactive 23Na+ was added only to the mucosal fluid to a final concentration ranging between 1 and 10 mM. Following this addition, clearance changed from a state of spontaneous decline to one of progressive increase. The average rate of increase was 37%/h.3.3. The period of progressive increase (slow cis-stimulation) lasted an average of 2 h; afterwards clearance spontaneously began to decrease progressively.4.4. On the average, the peak value of clearance was 2.2 times the value of clearance at the time 23Na+ was added.5.5. Even during the period of decline, the clearance did not return to the level at which it would have been if Na+ had not been added to the mucosal fluid.6.6. Washout of 22Na+ from the tissue pool subsequent to the addition of mucosal 23Na+ was eliminated as the explanation for the observed increase in clearance.7.7. Concomitant changes in short-circuiting current independently confirmed the validity of the slow cis-stimulation but also suggested that the movement of ions other than Na+ may have been affected by slow cis-stimulation." @default.
- W1981308974 created "2016-06-24" @default.
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- W1981308974 date "1969-08-01" @default.
- W1981308974 modified "2023-09-23" @default.
- W1981308974 title "Slow cis-stimulation of sodium tranport across isolated urinary bladders of the fresh-water turtle, Pseudemys scripta" @default.
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- W1981308974 doi "https://doi.org/10.1016/0005-2736(69)90171-0" @default.
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