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- W1981342655 abstract "Abstract The role of direct interactions between ion channels and general anesthetic agents, including 1-alkanols, is broadly recognized. Relevant models that may allow direct visualization of these interactions are critical for understanding the molecular bases of general anesthesia and alcohol intoxication. The Drosophila Shaw2 K+ channel is selectively modulated by 1-alkanols at pharmacologically relevant concentrations. From our studies, we have concluded that: (1) amphiphilic interactions control the binding of 1-alkanols to an intracellularly accessible site in the Shaw2 protein; and (2) the modulation (inhibition or potentiation) depends on the secondary structures of the S4–S5 loop and the distal region of the S6 segment, which are components of the main activation gate and may directly contribute to the 1-alkanol binding site. Here, we summarize our work and discuss ideas that may shed light on the structural basis of the modulation of the Shaw2 K+ channel by 1-alkanols." @default.
- W1981342655 created "2016-06-24" @default.
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- W1981342655 date "2005-11-01" @default.
- W1981342655 modified "2023-09-27" @default.
- W1981342655 title "Alcohol and anesthetic action at the gate of a voltage-dependent K+ channel" @default.
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- W1981342655 doi "https://doi.org/10.1016/j.ics.2005.06.045" @default.
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