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- W1981344227 endingPage "1031" @default.
- W1981344227 startingPage "1018" @default.
- W1981344227 abstract "The apolipoprotein E gene (APOE) has emerged as a candidate for prognosticating traumatic brain injury (TBI) recovery, with APOEε4 identified as a susceptibility marker for poor outcome, despite large discrepancy in its reported influence post-TBI.A systematic review was conducted, including all primary articles investigating the role of APOEε4 on TBI outcome. A total of 65 studies were included, including 24 predominantly investigating mild (mTBI), seven moderate (modTBI) and 33 severe (sTBI); severity was not reported in one study.In mTBI studies, the association between APOEε4 and post-TBI outcome was concluded as non-contributory in 14 studies (58.3%), hazardous in nine (37.5%) and protective in one (4.2%). In sTBI studies, the role of APOEε4 was hazardous in 21 (63.6%), non-contributory in nine (27.3%) and protective in three (9.1%). Of the seven studies investigating dementia outcomes, four observed a hazardous association with APOEε4, while three reported no association. Six studies examined Alzheimer's dementia pathology, of which three reported a hazardous influence of APOEε4.The influence of APOEε4 on neuropsychological testing, functional outcome and in paediatric populations was incongruous. This review supports the majority of research indicating APOEε4 adversely influences recovery following TBI, particularly with respect to dementia-related outcomes and outcomes following sTBI." @default.
- W1981344227 created "2016-06-24" @default.
- W1981344227 creator A5015849619 @default.
- W1981344227 creator A5032305645 @default.
- W1981344227 creator A5049572012 @default.
- W1981344227 creator A5080548305 @default.
- W1981344227 date "2015-04-27" @default.
- W1981344227 modified "2023-10-18" @default.
- W1981344227 title "The role of apolipoprotein E episilon (<b>ɛ</b>)-4 allele on outcome following traumatic brain injury: A systematic review" @default.
- W1981344227 cites W127880626 @default.
- W1981344227 cites W1490883923 @default.
- W1981344227 cites W1539817995 @default.
- W1981344227 cites W1557212676 @default.
- W1981344227 cites W1578076680 @default.
- W1981344227 cites W1611052574 @default.
- W1981344227 cites W1663695055 @default.
- W1981344227 cites W1681397537 @default.
- W1981344227 cites W1965496447 @default.
- W1981344227 cites W1966837563 @default.
- W1981344227 cites W1967863634 @default.
- W1981344227 cites W1969351289 @default.
- W1981344227 cites W1970176530 @default.
- W1981344227 cites W1970205747 @default.
- W1981344227 cites W1972243699 @default.
- W1981344227 cites W1973450922 @default.
- W1981344227 cites W1978665911 @default.
- W1981344227 cites W1979046034 @default.
- W1981344227 cites W1985859760 @default.
- W1981344227 cites W1986122428 @default.
- W1981344227 cites W1989211333 @default.
- W1981344227 cites W1989235817 @default.
- W1981344227 cites W1989546154 @default.
- W1981344227 cites W1989849719 @default.
- W1981344227 cites W1990768231 @default.
- W1981344227 cites W1993652378 @default.
- W1981344227 cites W1996154454 @default.
- W1981344227 cites W1997913988 @default.
- W1981344227 cites W1999738656 @default.
- W1981344227 cites W2005391270 @default.
- W1981344227 cites W2007453010 @default.
- W1981344227 cites W2007898025 @default.
- W1981344227 cites W2007986677 @default.
- W1981344227 cites W2010169691 @default.
- W1981344227 cites W2010390315 @default.
- W1981344227 cites W2017385058 @default.
- W1981344227 cites W2024016745 @default.
- W1981344227 cites W2024095904 @default.
- W1981344227 cites W2024723832 @default.
- W1981344227 cites W2025745331 @default.
- W1981344227 cites W2026535659 @default.
- W1981344227 cites W2027537647 @default.
- W1981344227 cites W2028245351 @default.
- W1981344227 cites W2028729448 @default.
- W1981344227 cites W2032689342 @default.
- W1981344227 cites W2032843602 @default.
- W1981344227 cites W2033278909 @default.
- W1981344227 cites W2034257854 @default.
- W1981344227 cites W2034968148 @default.
- W1981344227 cites W2042625373 @default.
- W1981344227 cites W2043482232 @default.
- W1981344227 cites W2045374218 @default.
- W1981344227 cites W2046231670 @default.
- W1981344227 cites W2046556661 @default.
- W1981344227 cites W2054217820 @default.
- W1981344227 cites W2054384828 @default.
- W1981344227 cites W2055079541 @default.
- W1981344227 cites W2055855232 @default.
- W1981344227 cites W2057766834 @default.
- W1981344227 cites W2061916198 @default.
- W1981344227 cites W2062075447 @default.
- W1981344227 cites W2062754529 @default.
- W1981344227 cites W2063295164 @default.
- W1981344227 cites W2066520613 @default.
- W1981344227 cites W2066811879 @default.
- W1981344227 cites W2067064610 @default.
- W1981344227 cites W2067398365 @default.
- W1981344227 cites W2067933297 @default.
- W1981344227 cites W2068330750 @default.
- W1981344227 cites W2069384791 @default.
- W1981344227 cites W2071970885 @default.
- W1981344227 cites W2072220916 @default.
- W1981344227 cites W2073640336 @default.
- W1981344227 cites W2074678189 @default.
- W1981344227 cites W2080688007 @default.
- W1981344227 cites W2081325915 @default.
- W1981344227 cites W2082224389 @default.
- W1981344227 cites W2082754133 @default.
- W1981344227 cites W2085362431 @default.
- W1981344227 cites W2094432571 @default.
- W1981344227 cites W2096010550 @default.
- W1981344227 cites W2097039472 @default.
- W1981344227 cites W2102693002 @default.
- W1981344227 cites W2105573095 @default.
- W1981344227 cites W2108027291 @default.
- W1981344227 cites W2115738813 @default.
- W1981344227 cites W2116475791 @default.
- W1981344227 cites W2118387485 @default.
- W1981344227 cites W2122045701 @default.