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• W1981344285 abstract "In the model organism Caenorhabditis elegans, UNC-112 is colocalized with PAT-3/β-integrin and is a critical protein in the formation of PAT-3-mediated adhesive structure in body-wall muscle cells. However, the signaling pathway downstream of PAT-3/UNC-112 is largely unknown. To clarify the signaling pathway from PAT-3/UNC-112 to the actin cytoskeleton, we searched for and identified a novel Dbl homology/pleckstrin homology (DH/PH) domain containing protein, UIG-1 (UNC-112-interacting guanine nucleotide exchange factor-1). UIG-1 was colocalized with UNC-112 at dense bodies in body-wall muscle cells. UIG-1 showed CDC-42-specific GEF activity in vitro and induced filopodia formation in NIH 3T3 cells. Depletion of CDC-42 or PAT-3 in the developmental stage, by RNAi, prevented the formation of continuous actin filament in body-wall muscle cells. Taken together, these results suggest that UIG-1 links a PAT-3/UNC-112 complex to the CDC-42 signaling pathway during muscle formation." @default.
• W1981344285 created "2016-06-24" @default.
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• W1981344285 date "2005-09-01" @default.
• W1981344285 modified "2023-09-27" @default.
• W1981344285 title "Identification of a novel Cdc42 GEF that is localized to the PAT-3-mediated adhesive structure" @default.
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• W1981344285 doi "https://doi.org/10.1016/j.bbrc.2005.07.068" @default.
• W1981344285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16055082" @default.
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