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• W1981350451 abstract "In this study, a new chelerythrine nanomaterial targeted drug delivery system (Fe3O4/MWNTs-CHE) was designed with chelerythrine (CHE) as model of antitumor drug and magnetic multiwalled carbon nanotubes (Fe3O4/MWNTs) nanocomposites as drug carrier. The process and formulation variables of Fe3O4/MWNTs-CHE were optimized using response surface methodology (RSM) with a three-level, three-factor Box–Behnken design (BBD). Mathematical equations and response surface plots were used to relate the dependent and independent variables. The experimental results were fitted into second-order response surface model. When Fe3O4/MWNTs:CHE ratio was 20.6:1, CHE concentration was 172.0 μg/mL, temperature was 34.5 °C, the drug loading content and entrapment efficiency were 3.04 ± 0.17% and 63.68 ± 2.36%, respectively. The optimized Fe3O4/MWNTs-CHE nanoparticles were characterized by scanning electron microscopy (SEM), Zeta potential, in vitro drug release and MTT assays. The in vitro CHE drug release behavior from Fe3O4/MWNTs-CHE displayed a biphasic drug release pattern and followed Korsmeyer–Peppas model with Fickian diffusion mechanism for drug release. The results from MTT assays suggested that the Fe3O4/MWNTs-CHE could effectively inhibit the proliferation of human hepatoma cells (HepG2), which displayed time or concentration-dependent manner. All these preliminary studies were expected to provide a theoretical basis and offer new methods for preparation efficient magnetic targeted drug delivery systems." @default.
• W1981350451 created "2016-06-24" @default.
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• W1981350451 date "2014-02-01" @default.
• W1981350451 modified "2023-10-16" @default.
• W1981350451 title "Optimization and evaluation of chelerythrine nanoparticles composed of magnetic multiwalled carbon nanotubes by response surface methodology" @default.
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• W1981350451 doi "https://doi.org/10.1016/j.apsusc.2013.11.148" @default.
• W1981350451 hasPublicationYear "2014" @default.
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