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• W1981352298 endingPage "97" @default.
• W1981352298 startingPage "81" @default.
• W1981352298 abstract "To identify prognostic factors and treatment toxicity in a series of operable endometrial adenocarcinomas.Between November 1971 and October 1992, 437 patients (pts) with endometrial carcinoma, staged according to the 1988 FIGO staging system (225 Stage IB, 107 Stage IC, 4 Stage IIA, 35 Stage IIB, 30 Stage IIIA, 6 Stage IIIB, and 30 Stage IIIC), underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy without (n = 140) or with (n = 297) pelvic lymph node dissection. The chronology of adjuvant RT was not randomized and depended on the usual practices of the surgical teams. Seventy-nine pts (Group I) received preoperative low-dose-rate uterovaginal brachytherapy (mean dose [MD]: 57 Gy). Three hundred fifty-eight pts (Group II) received postoperative RT. One hundred ninety-six pts received low-dose-rate vaginal brachytherapy alone (MD: 50 Gy). One hundred fifty-eight pts had external beam pelvic RT (MD: 46 Gy) followed by low-dose-rate vaginal brachytherapy (MD: 17 Gy). Four pts had external beam pelvic RT alone (MD: 47 Gy). The mean follow-up from the beginning of treatment was 128 months.The 10-year disease-free survival rate was 86%. From 57 recurrences, only 12 were isolated locoregional recurrences. The independent factors decreasing the probability of disease-free survival were as follows: histologic type (clear-cell carcinoma, p = 0.038), largest histologic tumor diameter >3 cm (p = 0.015), histologic grade (p = 0.008), myometrial invasion > 1/2 (p = 0.005), and 1988 FIGO staging system (p = 9.10(-8)). In Group II, the addition of external beam pelvic RT did not seem to independently improve vaginal or pelvic control. The postoperative complication rate was 7%. The independent factors increasing the risk of postoperative complications were stage FIGO (p = 0.02) and pelvic lymph node dissection (p = 0.011). The 10-year rate for Grade 3 and 4 late radiation complications according to the LENT-SOMA scoring system was 3.1%. External beam pelvic RT independently increased the rate for Grade 3 and 4 late complication (RR: 5.6, p = 0.0096).Postoperative external beam pelvic RT increases the risk of late radiation complications. After surgical and histopathologic staging with pelvic lymph node dissection, in subgroup of intermediate-risk patients (Stage IA Grade 3, IB-C and II), postoperative vaginal brachytherapy alone is probably sufficient to obtain a good therapeutic index. Results for patients with Stage III tumor are not satisfactory." @default.
• W1981352298 created "2016-06-24" @default.
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• W1981352298 date "2001-05-01" @default.
• W1981352298 modified "2023-10-18" @default.
• W1981352298 title "Adenocarcinoma of the endometrium treated with combined irradiation and surgery: Study of 437 patients" @default.
• W1981352298 cites W1654438595 @default.
• W1981352298 cites W1968244916 @default.
• W1981352298 cites W1968253256 @default.
• W1981352298 cites W1971326660 @default.
• W1981352298 cites W1976163500 @default.
• W1981352298 cites W1980606545 @default.
• W1981352298 cites W1982937278 @default.
• W1981352298 cites W1983052203 @default.
• W1981352298 cites W1986095928 @default.
• W1981352298 cites W1986419741 @default.
• W1981352298 cites W1988855646 @default.
• W1981352298 cites W1992321249 @default.
• W1981352298 cites W1994601570 @default.
• W1981352298 cites W1996799344 @default.
• W1981352298 cites W1996824037 @default.
• W1981352298 cites W1999089268 @default.
• W1981352298 cites W2000714566 @default.
• W1981352298 cites W2000828175 @default.
• W1981352298 cites W2002234295 @default.
• W1981352298 cites W2002612094 @default.
• W1981352298 cites W2002991620 @default.
• W1981352298 cites W2013000212 @default.
• W1981352298 cites W2013620685 @default.
• W1981352298 cites W2014996059 @default.
• W1981352298 cites W2016222118 @default.
• W1981352298 cites W2016421629 @default.
• W1981352298 cites W2016558284 @default.
• W1981352298 cites W2019137447 @default.
• W1981352298 cites W2023519144 @default.
• W1981352298 cites W2024469204 @default.
• W1981352298 cites W2026366091 @default.
• W1981352298 cites W2026530171 @default.
• W1981352298 cites W2027862992 @default.
• W1981352298 cites W2028517400 @default.
• W1981352298 cites W2029292517 @default.
• W1981352298 cites W2030653782 @default.
• W1981352298 cites W2032768962 @default.
• W1981352298 cites W2032997711 @default.
• W1981352298 cites W2043687307 @default.
• W1981352298 cites W2044590088 @default.
• W1981352298 cites W2046569169 @default.
• W1981352298 cites W2049501242 @default.
• W1981352298 cites W2050596640 @default.
• W1981352298 cites W2052789232 @default.
• W1981352298 cites W2053894234 @default.
• W1981352298 cites W2054910772 @default.
• W1981352298 cites W2056435763 @default.
• W1981352298 cites W2059611504 @default.
• W1981352298 cites W2064355269 @default.
• W1981352298 cites W2064419994 @default.
• W1981352298 cites W2067310977 @default.
• W1981352298 cites W2067796859 @default.
• W1981352298 cites W2070473789 @default.
• W1981352298 cites W2077087957 @default.
• W1981352298 cites W2078878330 @default.
• W1981352298 cites W2079095342 @default.
• W1981352298 cites W2079219224 @default.
• W1981352298 cites W2081579868 @default.
• W1981352298 cites W2083128092 @default.
• W1981352298 cites W2087331963 @default.
• W1981352298 cites W2090970424 @default.
• W1981352298 cites W2093868330 @default.
• W1981352298 cites W2094234256 @default.
• W1981352298 cites W2097409147 @default.
• W1981352298 cites W2099763306 @default.
• W1981352298 cites W2103408844 @default.
• W1981352298 cites W2104742468 @default.
• W1981352298 cites W2119315174 @default.
• W1981352298 cites W2125168783 @default.
• W1981352298 cites W2138232313 @default.
• W1981352298 cites W2141616721 @default.
• W1981352298 cites W2151251583 @default.
• W1981352298 cites W2151458592 @default.
• W1981352298 cites W2162698184 @default.
• W1981352298 cites W2163650867 @default.
• W1981352298 cites W2340522505 @default.
• W1981352298 cites W4205151458 @default.

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