Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981353467> ?p ?o ?g. }
- W1981353467 endingPage "3053" @default.
- W1981353467 startingPage "3048" @default.
- W1981353467 abstract "Progressive rod–cone degeneration ( prcd ) is the most widespread hereditary retinal disease leading to blindness in dogs and phenotypically is the canine counterpart of retinitis pigmentosa (RP) in humans. In previous efforts to identify the genetic locus for prcd, the canine homologs for many of the genes causally associated with RP in humans, such as RHO , PDE6B , and RDS /peripherin, have been excluded. In parallel with a recent undertaking to establish a framework map of the canine genome, multiple prcd -informative pedigrees have been typed with a panel of more than 100 anchor loci and microsatellite-based markers. Identification of a linkage group flanking prcd ([ TK1 , GALK1 , prcd ]–[ MYL4 , C09.173 , C09.2263 ]– RARA–C09.250–C09.474–NF1 ) localizes prcd close to the centromeric end of canine chromosome 9 (CFA9), and excludes RARA as a candidate gene. The conserved synteny of this region of CFA9 and distal human chromosome 17q establishes the potential locus homology of prcd in the dog with RP17, a human retinitis pigmentosa locus for which no gene has yet been identified. Assignment of the prcd disease locus to an identified canine autosome represents a powerful application of the developing canine linkage map in medical genetics. The usefulness of this approach is further demonstrated by identification of the correspondence of the prcd interval to homologous human and mouse chromosomal regions. The rapid progress that is now occurring in the field of canine genetics will expedite the identification of the genes underlying many of the inherited traits and diseases that make the dog a unique asset for the study of mammalian traits." @default.
- W1981353467 created "2016-06-24" @default.
- W1981353467 creator A5009729295 @default.
- W1981353467 creator A5016715548 @default.
- W1981353467 creator A5038166405 @default.
- W1981353467 creator A5045178497 @default.
- W1981353467 creator A5052203408 @default.
- W1981353467 creator A5053912575 @default.
- W1981353467 creator A5078087543 @default.
- W1981353467 creator A5081540003 @default.
- W1981353467 date "1998-03-17" @default.
- W1981353467 modified "2023-10-16" @default.
- W1981353467 title "Linkage analysis and comparative mapping of canine progressive rod–cone degeneration ( <i>prcd</i> ) establishes potential locus homology with retinitis pigmentosa (RP17) in humans" @default.
- W1981353467 cites W106582422 @default.
- W1981353467 cites W1246228224 @default.
- W1981353467 cites W1542221010 @default.
- W1981353467 cites W1588469160 @default.
- W1981353467 cites W1604929717 @default.
- W1981353467 cites W1964721639 @default.
- W1981353467 cites W1966039946 @default.
- W1981353467 cites W1968769254 @default.
- W1981353467 cites W1972591415 @default.
- W1981353467 cites W1975489737 @default.
- W1981353467 cites W1977381415 @default.
- W1981353467 cites W1978109605 @default.
- W1981353467 cites W1986202652 @default.
- W1981353467 cites W1988083344 @default.
- W1981353467 cites W1989963092 @default.
- W1981353467 cites W1992661776 @default.
- W1981353467 cites W1993437185 @default.
- W1981353467 cites W1999642472 @default.
- W1981353467 cites W2008023815 @default.
- W1981353467 cites W2012582259 @default.
- W1981353467 cites W2018586208 @default.
- W1981353467 cites W2022257217 @default.
- W1981353467 cites W2024717438 @default.
- W1981353467 cites W2031914648 @default.
- W1981353467 cites W2033037070 @default.
- W1981353467 cites W2034485231 @default.
- W1981353467 cites W2035999317 @default.
- W1981353467 cites W2049914565 @default.
- W1981353467 cites W2050748970 @default.
- W1981353467 cites W2055098860 @default.
- W1981353467 cites W2057790130 @default.
- W1981353467 cites W2064226143 @default.
- W1981353467 cites W2064414949 @default.
- W1981353467 cites W2065599814 @default.
- W1981353467 cites W2069197925 @default.
- W1981353467 cites W2072699141 @default.
- W1981353467 cites W2076151920 @default.
- W1981353467 cites W2077581829 @default.
- W1981353467 cites W2084968280 @default.
- W1981353467 cites W2090740451 @default.
- W1981353467 cites W2092199789 @default.
- W1981353467 cites W2092993130 @default.
- W1981353467 cites W2094767494 @default.
- W1981353467 cites W2140396743 @default.
- W1981353467 cites W2140812033 @default.
- W1981353467 cites W2323291414 @default.
- W1981353467 cites W2337979702 @default.
- W1981353467 cites W2435364203 @default.
- W1981353467 cites W8898199 @default.
- W1981353467 doi "https://doi.org/10.1073/pnas.95.6.3048" @default.
- W1981353467 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/19692" @default.
- W1981353467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9501213" @default.
- W1981353467 hasPublicationYear "1998" @default.
- W1981353467 type Work @default.
- W1981353467 sameAs 1981353467 @default.
- W1981353467 citedByCount "105" @default.
- W1981353467 countsByYear W19813534672012 @default.
- W1981353467 countsByYear W19813534672013 @default.
- W1981353467 countsByYear W19813534672014 @default.
- W1981353467 countsByYear W19813534672015 @default.
- W1981353467 countsByYear W19813534672016 @default.
- W1981353467 countsByYear W19813534672017 @default.
- W1981353467 countsByYear W19813534672018 @default.
- W1981353467 countsByYear W19813534672019 @default.
- W1981353467 countsByYear W19813534672020 @default.
- W1981353467 countsByYear W19813534672021 @default.
- W1981353467 countsByYear W19813534672023 @default.
- W1981353467 crossrefType "journal-article" @default.
- W1981353467 hasAuthorship W1981353467A5009729295 @default.
- W1981353467 hasAuthorship W1981353467A5016715548 @default.
- W1981353467 hasAuthorship W1981353467A5038166405 @default.
- W1981353467 hasAuthorship W1981353467A5045178497 @default.
- W1981353467 hasAuthorship W1981353467A5052203408 @default.
- W1981353467 hasAuthorship W1981353467A5053912575 @default.
- W1981353467 hasAuthorship W1981353467A5078087543 @default.
- W1981353467 hasAuthorship W1981353467A5081540003 @default.
- W1981353467 hasBestOaLocation W19813534672 @default.
- W1981353467 hasConcept C104317684 @default.
- W1981353467 hasConcept C127716648 @default.
- W1981353467 hasConcept C142870003 @default.
- W1981353467 hasConcept C200544954 @default.
- W1981353467 hasConcept C2781114197 @default.
- W1981353467 hasConcept C30481170 @default.
- W1981353467 hasConcept C53702515 @default.
- W1981353467 hasConcept C54355233 @default.