FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981353729> ?p ?o ?g. }

• W1981353729 endingPage "86" @default.
• W1981353729 startingPage "79" @default.
• W1981353729 abstract "Cochlear outer hair cells (OHCs) are polarized epithelial cells that have mechanoelectrical transduction channels within their apical stereocilia and produce electromotile force along their lateral wall. Phase shifts, or time delays, in the transmembrane voltage occurring at different axial locations along the cell may contribute to our understanding of how these cells operate at auditory frequencies. We developed a method to optically measure the phase of the OHC transmembrane potential using the voltage-sensitive dye (VSD) di-8-ANEPPS. The exit aperture of a fibre-optic light source was driven in two dimensions so that a 24 microm spot of excitation light could be positioned along the length of the OHC. We used the whole-cell patch-clamp technique in the current-clamp mode to stimulate the OHC at the base. The photometric response and the voltage response were monitored with a photodetector and patch-clamp amplifier, respectively. The photometric response was used to measure the regional changes in the membrane potential in response to maintained (dc) and sinusoidal (ac) current stimuli applied at the base of the cell. We used a neutral density filter to lower the excitation light intensity and reduce phototoxicity. A sensitive detector and lock-in amplifier were used to measure the small ac VSD signal. This permitted measurements of the ac photometric response below the noise floor of the static fluorescence. The amplitude and phase components of the photometric response were recorded for stimuli up to 800 Hz. VSD data at 400-800 Hz show the presence of a small phase delay between the stimulus voltage at the base of the cell and the local membrane potential measured along the lateral wall. Results are consistent with the hypothesis that OHCs exhibit inhomogeneous membrane potentials that vary with position in analogy with the voltage in nerve axons." @default.
• W1981353729 created "2016-06-24" @default.
• W1981353729 creator A5007921825 @default.
• W1981353729 creator A5032163850 @default.
• W1981353729 creator A5036557880 @default.
• W1981353729 creator A5043264771 @default.
• W1981353729 creator A5044806442 @default.
• W1981353729 date "2006-04-11" @default.
• W1981353729 modified "2023-09-26" @default.
• W1981353729 title "Photometric recording of transmembrane potential in outer hair cells" @default.
• W1981353729 cites W1580313606 @default.
• W1981353729 cites W1617123273 @default.
• W1981353729 cites W1653261439 @default.
• W1981353729 cites W175246874 @default.
• W1981353729 cites W1900274922 @default.
• W1981353729 cites W1968603844 @default.
• W1981353729 cites W1971182742 @default.
• W1981353729 cites W1971362414 @default.
• W1981353729 cites W1971996083 @default.
• W1981353729 cites W1983261693 @default.
• W1981353729 cites W1993740563 @default.
• W1981353729 cites W1996040599 @default.
• W1981353729 cites W1996449721 @default.
• W1981353729 cites W2006308487 @default.
• W1981353729 cites W2007264114 @default.
• W1981353729 cites W2009268668 @default.
• W1981353729 cites W2019307440 @default.
• W1981353729 cites W2029681013 @default.
• W1981353729 cites W2042598081 @default.
• W1981353729 cites W2062148835 @default.
• W1981353729 cites W2063637335 @default.
• W1981353729 cites W2069225430 @default.
• W1981353729 cites W2069825772 @default.
• W1981353729 cites W2074276238 @default.
• W1981353729 cites W2075467591 @default.
• W1981353729 cites W2075876013 @default.
• W1981353729 cites W2081439231 @default.
• W1981353729 cites W2091532427 @default.
• W1981353729 cites W2099386789 @default.
• W1981353729 cites W2108359562 @default.
• W1981353729 cites W2111762111 @default.
• W1981353729 cites W2114237429 @default.
• W1981353729 cites W2120778711 @default.
• W1981353729 cites W2126500861 @default.
• W1981353729 cites W2131921751 @default.
• W1981353729 cites W2149316724 @default.
• W1981353729 cites W2219416963 @default.
• W1981353729 cites W2316645994 @default.
• W1981353729 cites W4214868137 @default.
• W1981353729 doi "https://doi.org/10.1088/1741-2560/3/2/001" @default.
• W1981353729 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2716392" @default.
• W1981353729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16705263" @default.
• W1981353729 hasPublicationYear "2006" @default.
• W1981353729 type Work @default.
• W1981353729 sameAs 1981353729 @default.
• W1981353729 citedByCount "10" @default.
• W1981353729 countsByYear W19813537292012 @default.
• W1981353729 countsByYear W19813537292013 @default.
• W1981353729 countsByYear W19813537292015 @default.
• W1981353729 countsByYear W19813537292020 @default.
• W1981353729 countsByYear W19813537292021 @default.
• W1981353729 crossrefType "journal-article" @default.
• W1981353729 hasAuthorship W1981353729A5007921825 @default.
• W1981353729 hasAuthorship W1981353729A5032163850 @default.
• W1981353729 hasAuthorship W1981353729A5036557880 @default.
• W1981353729 hasAuthorship W1981353729A5043264771 @default.
• W1981353729 hasAuthorship W1981353729A5044806442 @default.
• W1981353729 hasBestOaLocation W19813537292 @default.
• W1981353729 hasConcept C100837961 @default.
• W1981353729 hasConcept C105702510 @default.
• W1981353729 hasConcept C120665830 @default.
• W1981353729 hasConcept C121332964 @default.
• W1981353729 hasConcept C12554922 @default.
• W1981353729 hasConcept C147944092 @default.
• W1981353729 hasConcept C169760540 @default.
• W1981353729 hasConcept C181911157 @default.
• W1981353729 hasConcept C185263204 @default.
• W1981353729 hasConcept C192562407 @default.
• W1981353729 hasConcept C194257627 @default.
• W1981353729 hasConcept C2777151030 @default.
• W1981353729 hasConcept C2778585322 @default.
• W1981353729 hasConcept C2780130748 @default.
• W1981353729 hasConcept C2780259410 @default.
• W1981353729 hasConcept C44280652 @default.
• W1981353729 hasConcept C46362747 @default.
• W1981353729 hasConcept C49040817 @default.
• W1981353729 hasConcept C54767332 @default.
• W1981353729 hasConcept C62520636 @default.
• W1981353729 hasConcept C86803240 @default.
• W1981353729 hasConceptScore W1981353729C100837961 @default.
• W1981353729 hasConceptScore W1981353729C105702510 @default.
• W1981353729 hasConceptScore W1981353729C120665830 @default.
• W1981353729 hasConceptScore W1981353729C121332964 @default.
• W1981353729 hasConceptScore W1981353729C12554922 @default.
• W1981353729 hasConceptScore W1981353729C147944092 @default.
• W1981353729 hasConceptScore W1981353729C169760540 @default.
• W1981353729 hasConceptScore W1981353729C181911157 @default.
• W1981353729 hasConceptScore W1981353729C185263204 @default.

• next