FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981361706> ?p ?o ?g. }

• W1981361706 endingPage "21986" @default.
• W1981361706 startingPage "21981" @default.
• W1981361706 abstract "TcTex-1, one of three dynein light chains of the dynein motor complex, has been implicated in targeting and binding cargoes to cytoplasmic dynein for retrograde or apical transport. Interactions between TcTex-1 and a diverse set of proteins such as the dynein intermediate chain, Fyn, DOC2, FIP1, the poliovirus receptor, CD155, and the rhodopsin cytoplasmic tail have been reported; yet, despite the broad range of targets, a consensus binding sequence remains uncertain. Consequently, we have solved the crystal structure of the full-length Drosophila homolog of TcTex-1 to 1.7 A resolution using MAD phasing to gain insight into its function and target specificity. The structure is homodimeric with a domain swapping of β-strand 2 and has a fold similar to the dynein light chain, LC8. Based on structural alignment, the TcTex-1 and LC8 sequences show no identity, although the root mean square deviation between secondary structural elements is less than 1.6 A. Moreover, the N terminus, which is equivalent to β-strand 1 in LC8, is splayed out and binds to a crystallographic dimer as an anti-parallel β-strand at the same position as the neuronal nitric-oxide synthase peptide in the LC8 complex. Similarity to LC8 and comparison to the LC8-neuronal nitricoxide synthase complex suggest that TcTex-1 binds its targets in a similar manner as LC8 and provides insight to the lack of strict sequence identity among the targets for TcTex-1." @default.
• W1981361706 created "2016-06-24" @default.
• W1981361706 creator A5026978349 @default.
• W1981361706 creator A5030659071 @default.
• W1981361706 creator A5077318372 @default.
• W1981361706 date "2005-06-01" @default.
• W1981361706 modified "2023-09-30" @default.
• W1981361706 title "Crystal Structure of Dynein Light Chain TcTex-1" @default.
• W1981361706 cites W1506811553 @default.
• W1981361706 cites W153791503 @default.
• W1981361706 cites W1822348693 @default.
• W1981361706 cites W1832474731 @default.
• W1981361706 cites W1965670405 @default.
• W1981361706 cites W1967582433 @default.
• W1981361706 cites W1969222787 @default.
• W1981361706 cites W1981166298 @default.
• W1981361706 cites W1986575850 @default.
• W1981361706 cites W1988130222 @default.
• W1981361706 cites W1995017064 @default.
• W1981361706 cites W2001641653 @default.
• W1981361706 cites W2001860659 @default.
• W1981361706 cites W2012660700 @default.
• W1981361706 cites W2014087205 @default.
• W1981361706 cites W2020234447 @default.
• W1981361706 cites W2022998391 @default.
• W1981361706 cites W2029582401 @default.
• W1981361706 cites W2034824822 @default.
• W1981361706 cites W2036007339 @default.
• W1981361706 cites W2045465799 @default.
• W1981361706 cites W2047898830 @default.
• W1981361706 cites W2055147527 @default.
• W1981361706 cites W2055895995 @default.
• W1981361706 cites W2072278366 @default.
• W1981361706 cites W2074986801 @default.
• W1981361706 cites W2089072197 @default.
• W1981361706 cites W2089483026 @default.
• W1981361706 cites W2092987196 @default.
• W1981361706 cites W2096526911 @default.
• W1981361706 cites W2102150801 @default.
• W1981361706 cites W2103617829 @default.
• W1981361706 cites W2103884241 @default.
• W1981361706 cites W2109623198 @default.
• W1981361706 cites W2112724834 @default.
• W1981361706 cites W2118200380 @default.
• W1981361706 cites W2120533372 @default.
• W1981361706 cites W2139741312 @default.
• W1981361706 cites W2141372231 @default.
• W1981361706 cites W2143764490 @default.
• W1981361706 cites W2150009705 @default.
• W1981361706 cites W2157468803 @default.
• W1981361706 cites W2167647748 @default.
• W1981361706 cites W2398225480 @default.
• W1981361706 cites W2416963084 @default.
• W1981361706 cites W295338928 @default.
• W1981361706 doi "https://doi.org/10.1074/jbc.m414643200" @default.
• W1981361706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15701632" @default.
• W1981361706 hasPublicationYear "2005" @default.
• W1981361706 type Work @default.
• W1981361706 sameAs 1981361706 @default.
• W1981361706 citedByCount "44" @default.
• W1981361706 countsByYear W19813617062012 @default.
• W1981361706 countsByYear W19813617062013 @default.
• W1981361706 countsByYear W19813617062014 @default.
• W1981361706 countsByYear W19813617062015 @default.
• W1981361706 countsByYear W19813617062016 @default.
• W1981361706 countsByYear W19813617062017 @default.
• W1981361706 countsByYear W19813617062018 @default.
• W1981361706 countsByYear W19813617062020 @default.
• W1981361706 countsByYear W19813617062021 @default.
• W1981361706 countsByYear W19813617062022 @default.
• W1981361706 countsByYear W19813617062023 @default.
• W1981361706 crossrefType "journal-article" @default.
• W1981361706 hasAuthorship W1981361706A5026978349 @default.
• W1981361706 hasAuthorship W1981361706A5030659071 @default.
• W1981361706 hasAuthorship W1981361706A5077318372 @default.
• W1981361706 hasBestOaLocation W19813617061 @default.
• W1981361706 hasConcept C106987784 @default.
• W1981361706 hasConcept C121332964 @default.
• W1981361706 hasConcept C1276947 @default.
• W1981361706 hasConcept C159654299 @default.
• W1981361706 hasConcept C185592680 @default.
• W1981361706 hasConcept C199185054 @default.
• W1981361706 hasConcept C20418707 @default.
• W1981361706 hasConcept C36394416 @default.
• W1981361706 hasConcept C54355233 @default.
• W1981361706 hasConcept C8010536 @default.
• W1981361706 hasConcept C86803240 @default.
• W1981361706 hasConcept C95444343 @default.
• W1981361706 hasConceptScore W1981361706C106987784 @default.
• W1981361706 hasConceptScore W1981361706C121332964 @default.
• W1981361706 hasConceptScore W1981361706C1276947 @default.
• W1981361706 hasConceptScore W1981361706C159654299 @default.
• W1981361706 hasConceptScore W1981361706C185592680 @default.
• W1981361706 hasConceptScore W1981361706C199185054 @default.
• W1981361706 hasConceptScore W1981361706C20418707 @default.
• W1981361706 hasConceptScore W1981361706C36394416 @default.
• W1981361706 hasConceptScore W1981361706C54355233 @default.
• W1981361706 hasConceptScore W1981361706C8010536 @default.

• next