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- W1981371678 abstract "Background: A combination of hepatitis A and hepatitis B monovalent vaccines could offer advantages for disease control programs in terms of convenience, compliance and cost. Methods: Under randomized, double-blind conditions, 156 healthy young adults were divided into 3 groups to receive 1 of 3 lots of a combined hepatitis A/hepatitis B vaccine administered at months 0, 1, and 6. Safety and immunogenicity were assessed after each dose. Results: Transient and predominantly mild reactions were reported by slightly more than half the vaccinees; no serious adverse effects were related to vaccination. One month after dose 2, all subjects had converted to the hepatitis A component. Geometric mean titers (GMTs) of antibodies to hepatitis A virus varied from 4415 to 4882 mIU/ml in the three groups. For hepatitis B, most vaccinees (73%–92%) had protective levels of antibodies to hepatitis B virus (anti-HBs) after the second dose, and all were sero-protected after the booster. Anti-HBs GMTs at month 7 ranged from 1917 to 3298 mIU/ml. Conclusion: No statistically significant differences were observed between vaccine lots. The combined hepatitis A/hepatitis B vaccine was safe and clinically well tolerated and induced immune responses quantitatively similar to those obtained with the respective monovalent vaccines." @default.
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- W1981371678 date "1996-01-01" @default.
- W1981371678 modified "2023-09-27" @default.
- W1981371678 title "Safety and Immunogenicity of a Combined Hepatitis A and Hepatitis B Vaccine in Young Healthy Adults" @default.
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- W1981371678 doi "https://doi.org/10.3109/00365529609003124" @default.
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