FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981382912> ?p ?o ?g. }

• W1981382912 endingPage "34" @default.
• W1981382912 startingPage "21" @default.
• W1981382912 abstract "Metastatic melanoma is a highly life-threatening disease. The lack of response to radiotherapy and chemotherapy highlights the critical need for novel treatments. Parthenolide, an active component of feverfew (Tanacetum parthenium), inhibits proliferation and kills various cancer cells mainly by inducing apoptosis. The aim of the study was to examine anticancer effects of parthenolide in melanoma cells in vitro. The cytotoxicity of parthenolide was tested in melanoma cell lines and melanocytes, as well as melanoma cells directly derived from a surgical excision. Adherent cell proliferation was measured by tetrazolium derivative reduction assay. Loss of the plasma membrane integrity, hypodiploid events, reactive oxygen species generation, mitochondrial membrane potential dissipation, and caspase-3 activity were assessed by flow cytometric analysis. Microscopy was used to observe morphological changes and cell detachment. Parthenolide reduced the number of viable adherent cells in melanoma cultures. Half maximal inhibitory concentration values around 4 μmol/l were determined. Cell death accompanied by mitochondrial membrane depolarization and caspase-3 activation was observed as the result of parthenolide application. Interestingly, the melanoma cells from vertical growth phase and melanocytes were less susceptible to parthenolide-induced cell death than metastatic cells when drug concentration was at least 6 μmol/l. Reactive oxygen species level was not significantly increased in melanoma cells. However, preincubation of parthenolide with the thiol nucleophile N-acetyl-cysteine protected melanoma cells from parthenolide-induced cell death suggesting the reaction with intracellular thiols as the mechanism responsible for parthenolide activity. In conclusion, the observed anticancer activity makes parthenolide an attractive drug candidate for further testing in melanoma therapy." @default.
• W1981382912 created "2016-06-24" @default.
• W1981382912 creator A5001934449 @default.
• W1981382912 creator A5018295802 @default.
• W1981382912 creator A5045988492 @default.
• W1981382912 creator A5070332247 @default.
• W1981382912 creator A5072034828 @default.
• W1981382912 creator A5080990868 @default.
• W1981382912 date "2010-02-01" @default.
• W1981382912 modified "2023-09-30" @default.
• W1981382912 title "Parthenolide, a sesquiterpene lactone from the medical herb feverfew, shows anticancer activity against human melanoma cells in vitro" @default.
• W1981382912 cites W1580870868 @default.
• W1981382912 cites W1964427001 @default.
• W1981382912 cites W1966153837 @default.
• W1981382912 cites W1966340589 @default.
• W1981382912 cites W1967537433 @default.
• W1981382912 cites W1967560767 @default.
• W1981382912 cites W1970195561 @default.
• W1981382912 cites W1976294091 @default.
• W1981382912 cites W1983014406 @default.
• W1981382912 cites W1989220451 @default.
• W1981382912 cites W1991129555 @default.
• W1981382912 cites W1997039314 @default.
• W1981382912 cites W1998107133 @default.
• W1981382912 cites W2002161457 @default.
• W1981382912 cites W2009291628 @default.
• W1981382912 cites W2009604514 @default.
• W1981382912 cites W2016886090 @default.
• W1981382912 cites W2017130328 @default.
• W1981382912 cites W2018789635 @default.
• W1981382912 cites W2019065245 @default.
• W1981382912 cites W2020483122 @default.
• W1981382912 cites W2022683869 @default.
• W1981382912 cites W2025672321 @default.
• W1981382912 cites W2026715976 @default.
• W1981382912 cites W2026970599 @default.
• W1981382912 cites W2027765015 @default.
• W1981382912 cites W2030213143 @default.
• W1981382912 cites W2031991098 @default.
• W1981382912 cites W2037451324 @default.
• W1981382912 cites W2037848474 @default.
• W1981382912 cites W2041406428 @default.
• W1981382912 cites W2049169526 @default.
• W1981382912 cites W2057653416 @default.
• W1981382912 cites W2057948598 @default.
• W1981382912 cites W2058973529 @default.
• W1981382912 cites W2061460326 @default.
• W1981382912 cites W2065741295 @default.
• W1981382912 cites W2068156739 @default.
• W1981382912 cites W2072569544 @default.
• W1981382912 cites W2081527131 @default.
• W1981382912 cites W2090450481 @default.
• W1981382912 cites W2099068827 @default.
• W1981382912 cites W2099079381 @default.
• W1981382912 cites W2106785049 @default.
• W1981382912 cites W2109351911 @default.
• W1981382912 cites W2110200046 @default.
• W1981382912 cites W2115214814 @default.
• W1981382912 cites W2127364075 @default.
• W1981382912 cites W2137705897 @default.
• W1981382912 cites W2149609961 @default.
• W1981382912 cites W2152606604 @default.
• W1981382912 cites W2160271308 @default.
• W1981382912 cites W4232678241 @default.
• W1981382912 cites W4383058088 @default.
• W1981382912 doi "https://doi.org/10.1097/cmr.0b013e328333bbe4" @default.
• W1981382912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19949351" @default.
• W1981382912 hasPublicationYear "2010" @default.
• W1981382912 type Work @default.
• W1981382912 sameAs 1981382912 @default.
• W1981382912 citedByCount "75" @default.
• W1981382912 countsByYear W19813829122012 @default.
• W1981382912 countsByYear W19813829122013 @default.
• W1981382912 countsByYear W19813829122014 @default.
• W1981382912 countsByYear W19813829122015 @default.
• W1981382912 countsByYear W19813829122016 @default.
• W1981382912 countsByYear W19813829122017 @default.
• W1981382912 countsByYear W19813829122018 @default.
• W1981382912 countsByYear W19813829122019 @default.
• W1981382912 countsByYear W19813829122020 @default.
• W1981382912 countsByYear W19813829122021 @default.
• W1981382912 countsByYear W19813829122022 @default.
• W1981382912 countsByYear W19813829122023 @default.
• W1981382912 crossrefType "journal-article" @default.
• W1981382912 hasAuthorship W1981382912A5001934449 @default.
• W1981382912 hasAuthorship W1981382912A5018295802 @default.
• W1981382912 hasAuthorship W1981382912A5045988492 @default.
• W1981382912 hasAuthorship W1981382912A5070332247 @default.
• W1981382912 hasAuthorship W1981382912A5072034828 @default.
• W1981382912 hasAuthorship W1981382912A5080990868 @default.
• W1981382912 hasConcept C117262875 @default.
• W1981382912 hasConcept C185592680 @default.
• W1981382912 hasConcept C190283241 @default.
• W1981382912 hasConcept C2776211264 @default.
• W1981382912 hasConcept C2777658100 @default.
• W1981382912 hasConcept C2779243328 @default.
• W1981382912 hasConcept C2780321935 @default.
• W1981382912 hasConcept C31573885 @default.

• next