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- W1981407784 abstract "Metabolism and uptake of L-[1-14C]pipecolate was studied in the rat through tail vein injection at low (30 μg/kg) and high (30 mg/kg) doses. No radioactive compound other than L-pipecolate was detected in the brain or heart samples 0.5 to 60 min after injection. The contents of L-pipecolate in the brain dropped rapidly to reach a plateau value 2 min after injection both in the low and high dose experiments (from 0.06 to 0.05 and from 86 to 55 nmole/g brain, respectively). Similar results were observed for the heart except that the heart had L-pipecolate contents 2–3 fold higher than the brain at every time interval. The influx of L-pipecolate to the brain, as measured by the plasma/brain ratio of its contents, was 3 fold lower than the heart at each sampling point throughout the course of measurement for both dosages. The influx of L-pipecolate from the plasma to the heart reached an equilibrium, i.e., plasma/heart = 1, 60 min after injection for both dosages; the plasma to brain ratio was 3 at 60 min. These results indicate that there is a blood-brain transport barrier for L-pipecolate in the rat, which may account for the differences in neuronal effects of L-pipecolate when administered intracerebrally or intraperitoneally." @default.
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- W1981407784 date "1981-08-01" @default.
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- W1981407784 title "Metabolism and uptake of -pipecolic acid by brain and heart" @default.
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- W1981407784 doi "https://doi.org/10.1016/0024-3205(81)90397-0" @default.
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