Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981410927> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1981410927 endingPage "802" @default.
- W1981410927 startingPage "798" @default.
- W1981410927 abstract "The microbial transformation of the 17α-ethynyl-17β-hydroxyandrost-4-en-3-one (1) (ethisterone) and 17α-ethyl-17β-hydroxyandrost-4-en-3-one (2) by the fungi Cephalosporium aphidicola and Cunninghamella elegans were investigated. Incubation of compound 1 with C. aphidicola afforded oxidized derivative, 17α-ethynyl-17β-hydroxyandrosta-1,4-dien-3-one (3), while with C. elegans afforded a new hydroxy derivative, 17α-ethynyl-11α,17β-dihydroxyandrost-4-en-3-one (4). On the other hand, the incubation of compound 2 with the fungus C. aphidicola afforded 17α-ethyl-17β-hydroxyandrosta-1,4-dien-3-one (5). Two new hydroxylated derivatives, 17α-ethyl-11α,17β-dihydroxyandrost-4-en-3-one (6) and 17α-ethyl-6α,17β-dihydroxy-5α-androstan-3-one (7) were obtained from the incubation of compound 2 with C. elegans. Compounds 1–6 exhibited tyrosinase inhibitory activity, with compound 6 being the most potent member (IC50 = 1.72 μM)." @default.
- W1981410927 created "2016-06-24" @default.
- W1981410927 creator A5040577138 @default.
- W1981410927 creator A5053782853 @default.
- W1981410927 creator A5059584871 @default.
- W1981410927 creator A5063632267 @default.
- W1981410927 date "2005-11-01" @default.
- W1981410927 modified "2023-09-26" @default.
- W1981410927 title "Microbial transformation of 17α-ethynyl- and 17α-ethylsteroids, and tyrosinase inhibitory activity of transformed products" @default.
- W1981410927 cites W1925274588 @default.
- W1981410927 cites W2022351089 @default.
- W1981410927 cites W2025421738 @default.
- W1981410927 cites W2038742256 @default.
- W1981410927 cites W2040818475 @default.
- W1981410927 cites W2089331428 @default.
- W1981410927 cites W2095538836 @default.
- W1981410927 doi "https://doi.org/10.1016/j.steroids.2005.05.002" @default.
- W1981410927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16054181" @default.
- W1981410927 hasPublicationYear "2005" @default.
- W1981410927 type Work @default.
- W1981410927 sameAs 1981410927 @default.
- W1981410927 citedByCount "38" @default.
- W1981410927 countsByYear W19814109272012 @default.
- W1981410927 countsByYear W19814109272013 @default.
- W1981410927 countsByYear W19814109272014 @default.
- W1981410927 countsByYear W19814109272015 @default.
- W1981410927 countsByYear W19814109272017 @default.
- W1981410927 countsByYear W19814109272019 @default.
- W1981410927 countsByYear W19814109272020 @default.
- W1981410927 crossrefType "journal-article" @default.
- W1981410927 hasAuthorship W1981410927A5040577138 @default.
- W1981410927 hasAuthorship W1981410927A5053782853 @default.
- W1981410927 hasAuthorship W1981410927A5059584871 @default.
- W1981410927 hasAuthorship W1981410927A5063632267 @default.
- W1981410927 hasConcept C104317684 @default.
- W1981410927 hasConcept C106159729 @default.
- W1981410927 hasConcept C111771559 @default.
- W1981410927 hasConcept C162324750 @default.
- W1981410927 hasConcept C181199279 @default.
- W1981410927 hasConcept C185592680 @default.
- W1981410927 hasConcept C202751555 @default.
- W1981410927 hasConcept C204241405 @default.
- W1981410927 hasConcept C25642318 @default.
- W1981410927 hasConcept C2777752497 @default.
- W1981410927 hasConcept C2779678110 @default.
- W1981410927 hasConcept C55493867 @default.
- W1981410927 hasConcept C59822182 @default.
- W1981410927 hasConcept C71240020 @default.
- W1981410927 hasConcept C86803240 @default.
- W1981410927 hasConcept C87554066 @default.
- W1981410927 hasConceptScore W1981410927C104317684 @default.
- W1981410927 hasConceptScore W1981410927C106159729 @default.
- W1981410927 hasConceptScore W1981410927C111771559 @default.
- W1981410927 hasConceptScore W1981410927C162324750 @default.
- W1981410927 hasConceptScore W1981410927C181199279 @default.
- W1981410927 hasConceptScore W1981410927C185592680 @default.
- W1981410927 hasConceptScore W1981410927C202751555 @default.
- W1981410927 hasConceptScore W1981410927C204241405 @default.
- W1981410927 hasConceptScore W1981410927C25642318 @default.
- W1981410927 hasConceptScore W1981410927C2777752497 @default.
- W1981410927 hasConceptScore W1981410927C2779678110 @default.
- W1981410927 hasConceptScore W1981410927C55493867 @default.
- W1981410927 hasConceptScore W1981410927C59822182 @default.
- W1981410927 hasConceptScore W1981410927C71240020 @default.
- W1981410927 hasConceptScore W1981410927C86803240 @default.
- W1981410927 hasConceptScore W1981410927C87554066 @default.
- W1981410927 hasIssue "12" @default.
- W1981410927 hasLocation W19814109271 @default.
- W1981410927 hasLocation W19814109272 @default.
- W1981410927 hasOpenAccess W1981410927 @default.
- W1981410927 hasPrimaryLocation W19814109271 @default.
- W1981410927 hasRelatedWork W2026634374 @default.
- W1981410927 hasRelatedWork W2038531352 @default.
- W1981410927 hasRelatedWork W2041228289 @default.
- W1981410927 hasRelatedWork W2415217968 @default.
- W1981410927 hasRelatedWork W2947310919 @default.
- W1981410927 hasRelatedWork W2949961512 @default.
- W1981410927 hasRelatedWork W2952540846 @default.
- W1981410927 hasRelatedWork W2970050320 @default.
- W1981410927 hasRelatedWork W3204510291 @default.
- W1981410927 hasRelatedWork W4280631256 @default.
- W1981410927 hasVolume "70" @default.
- W1981410927 isParatext "false" @default.
- W1981410927 isRetracted "false" @default.
- W1981410927 magId "1981410927" @default.
- W1981410927 workType "article" @default.